ID   RPA12_BOVIN             Reviewed;         123 AA.
AC   Q1RMP0;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=DNA-directed RNA polymerase I subunit RPA12 {ECO:0000250|UniProtKB:Q9P1U0};
DE   AltName: Full=DNA-directed RNA polymerase I subunit H {ECO:0000250|UniProtKB:Q9P1U0};
GN   Name=POLR1H {ECO:0000250|UniProtKB:Q9P1U0};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Component of RNA polymerase I which synthesizes ribosomal RNA
CC       precursors.
CC   -!- SUBUNIT: Component of the RNA polymerase I (Pol I) complex consisting
CC       of at least 13 subunits.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P32529}.
CC   -!- SIMILARITY: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11
CC       RNA polymerase family. {ECO:0000305}.
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DR   EMBL; BC114799; AAI14800.1; -; mRNA.
DR   RefSeq; NP_001039865.1; NM_001046400.2.
DR   AlphaFoldDB; Q1RMP0; -.
DR   SMR; Q1RMP0; -.
DR   STRING; 9913.ENSBTAP00000042491; -.
DR   PaxDb; Q1RMP0; -.
DR   Ensembl; ENSBTAT00000045075; ENSBTAP00000042491; ENSBTAG00000031792.
DR   GeneID; 535288; -.
DR   KEGG; bta:535288; -.
DR   CTD; 30834; -.
DR   VEuPathDB; HostDB:ENSBTAG00000031792; -.
DR   VGNC; VGNC:37362; POLR1H.
DR   eggNOG; KOG2907; Eukaryota.
DR   GeneTree; ENSGT00390000008126; -.
DR   HOGENOM; CLU_093932_1_2_1; -.
DR   InParanoid; Q1RMP0; -.
DR   OMA; EMQYHTL; -.
DR   OrthoDB; 1456544at2759; -.
DR   TreeFam; TF313881; -.
DR   Reactome; R-BTA-5250924; B-WICH complex positively regulates rRNA expression.
DR   Reactome; R-BTA-73762; RNA Polymerase I Transcription Initiation.
DR   Proteomes; UP000009136; Chromosome 23.
DR   Bgee; ENSBTAG00000031792; Expressed in oocyte and 107 other tissues.
DR   GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006379; P:mRNA cleavage; IEA:InterPro.
DR   GO; GO:0006363; P:termination of RNA polymerase I transcription; IBA:GO_Central.
DR   CDD; cd10507; Zn-ribbon_RPA12; 1.
DR   InterPro; IPR019761; DNA-dir_RNA_pol-M_15_CS.
DR   InterPro; IPR012164; Rpa12/Rpb9/Rpc10/TFS.
DR   InterPro; IPR034004; Zn_ribbon_RPA12_C.
DR   InterPro; IPR001222; Znf_TFIIS.
DR   PANTHER; PTHR11239; PTHR11239; 1.
DR   Pfam; PF01096; TFIIS_C; 1.
DR   PIRSF; PIRSF005586; RNApol_RpoM; 1.
DR   SMART; SM00440; ZnF_C2C2; 1.
DR   PROSITE; PS01030; RNA_POL_M_15KD; 1.
DR   PROSITE; PS00466; ZF_TFIIS_1; 1.
DR   PROSITE; PS51133; ZF_TFIIS_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-directed RNA polymerase; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Zinc; Zinc-finger.
FT   CHAIN           1..123
FT                   /note="DNA-directed RNA polymerase I subunit RPA12"
FT                   /id="PRO_0000245339"
FT   ZN_FING         17..38
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         80..120
FT                   /note="TFIIS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         84
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         87
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         112
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         115
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
SQ   SEQUENCE   123 AA;  13505 MW;  30678EE256CB9142 CRC64;
     MDLAGICSSF QSDLDFCPDC GSVLPLPGVQ DAVACTRCGF SINVRDFEGK VVKTSVVFNK
     LGTAMPLSME EGPEFQGPVV DRRCSRCGHE GMAYHTRQMR SADEGQTVFY TCTNCKFQEK
     EDS