ID   RPA12_MACMU             Reviewed;         126 AA.
AC   Q5TM50;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA-directed RNA polymerase I subunit RPA12 {ECO:0000250|UniProtKB:Q9P1U0};
DE   AltName: Full=DNA-directed RNA polymerase I subunit H {ECO:0000250|UniProtKB:Q9P1U0};
GN   Name=POLR1H {ECO:0000250|UniProtKB:Q9P1U0};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15269276; DOI=10.1093/molbev/msh216;
RA   Kulski J.K., Anzai T., Shiina T., Inoko H.;
RT   "Rhesus macaque class I duplicon structures, organization, and evolution
RT   within the alpha block of the major histocompatibility complex.";
RL   Mol. Biol. Evol. 21:2079-2091(2004).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Component of RNA polymerase I which synthesizes ribosomal RNA
CC       precursors.
CC   -!- SUBUNIT: Component of the RNA polymerase I (Pol I) complex consisting
CC       of at least 13 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P32529}.
CC   -!- SIMILARITY: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11
CC       RNA polymerase family. {ECO:0000305}.
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DR   EMBL; AB128049; BAD69776.1; -; Genomic_DNA.
DR   RefSeq; NP_001108417.1; NM_001114945.1.
DR   RefSeq; XP_014991334.1; XM_015135848.1.
DR   RefSeq; XP_014991335.1; XM_015135849.1.
DR   AlphaFoldDB; Q5TM50; -.
DR   SMR; Q5TM50; -.
DR   STRING; 9544.ENSMMUP00000015890; -.
DR   Ensembl; ENSMMUT00000016967; ENSMMUP00000015890; ENSMMUG00000012120.
DR   GeneID; 712151; -.
DR   KEGG; mcc:712151; -.
DR   CTD; 30834; -.
DR   VEuPathDB; HostDB:ENSMMUG00000012120; -.
DR   VGNC; VGNC:78912; POLR1H.
DR   eggNOG; KOG2907; Eukaryota.
DR   GeneTree; ENSGT00390000008126; -.
DR   InParanoid; Q5TM50; -.
DR   OrthoDB; 1456544at2759; -.
DR   Proteomes; UP000006718; Chromosome 4.
DR   Bgee; ENSMMUG00000012120; Expressed in ileum and 21 other tissues.
DR   ExpressionAtlas; Q5TM50; baseline.
DR   GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006379; P:mRNA cleavage; IEA:InterPro.
DR   GO; GO:0006363; P:termination of RNA polymerase I transcription; IBA:GO_Central.
DR   CDD; cd10507; Zn-ribbon_RPA12; 1.
DR   InterPro; IPR019761; DNA-dir_RNA_pol-M_15_CS.
DR   InterPro; IPR012164; Rpa12/Rpb9/Rpc10/TFS.
DR   InterPro; IPR034004; Zn_ribbon_RPA12_C.
DR   InterPro; IPR001222; Znf_TFIIS.
DR   PANTHER; PTHR11239; PTHR11239; 1.
DR   Pfam; PF01096; TFIIS_C; 1.
DR   PIRSF; PIRSF005586; RNApol_RpoM; 1.
DR   SMART; SM00440; ZnF_C2C2; 1.
DR   PROSITE; PS01030; RNA_POL_M_15KD; 1.
DR   PROSITE; PS00466; ZF_TFIIS_1; 1.
DR   PROSITE; PS51133; ZF_TFIIS_2; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Zinc; Zinc-finger.
FT   CHAIN           1..126
FT                   /note="DNA-directed RNA polymerase I subunit RPA12"
FT                   /id="PRO_0000121461"
FT   ZN_FING         20..41
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         83..123
FT                   /note="TFIIS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         87
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         90
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         115
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         118
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
SQ   SEQUENCE   126 AA;  13835 MW;  E2647DBC276412D8 CRC64;
     MSVMDLAGTC SSFQSDLDFC SDCGSVLPLP GAQDTVTCTR CGFNINVRDF EGKVVKTSVV
     FHQLGTAMPM SVEEGPECQG PVVDRRCPRC GHEGMAYHTR QMRSADEGQT VFYTCTNCKF
     QEKEDS