RPA12_PANTR
ID RPA12_PANTR Reviewed; 126 AA.
AC Q1XHV8;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=DNA-directed RNA polymerase I subunit RPA12 {ECO:0000250|UniProtKB:Q9P1U0};
DE AltName: Full=DNA-directed RNA polymerase I subunit H {ECO:0000250|UniProtKB:Q9P1U0};
GN Name=POLR1H {ECO:0000250|UniProtKB:Q9P1U0};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16702430; DOI=10.1534/genetics.106.057034;
RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M.,
RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K.,
RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.,
RA Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T.,
RA Inoko H., Bahram S.;
RT "Rapid evolution of major histocompatibility complex class I genes in
RT primates generates new disease alleles in humans via hitchhiking
RT diversity.";
RL Genetics 173:1555-1570(2006).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Component of RNA polymerase I which synthesizes ribosomal RNA
CC precursors.
CC -!- SUBUNIT: Component of the RNA polymerase I (Pol I) complex consisting
CC of at least 13 subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:P32529}.
CC -!- SIMILARITY: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11
CC RNA polymerase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB210195; BAE92809.1; -; Genomic_DNA.
DR EMBL; AB210196; BAE92812.1; -; Genomic_DNA.
DR RefSeq; NP_001065276.1; NM_001071808.1.
DR RefSeq; XP_009449130.1; XM_009450855.2.
DR RefSeq; XP_009449131.1; XM_009450856.2.
DR RefSeq; XP_016810193.1; XM_016954704.1.
DR AlphaFoldDB; Q1XHV8; -.
DR SMR; Q1XHV8; -.
DR STRING; 9598.ENSPTRP00000030553; -.
DR PaxDb; Q1XHV8; -.
DR Ensembl; ENSPTRT00000033072; ENSPTRP00000030553; ENSPTRG00000017914.
DR GeneID; 471952; -.
DR KEGG; ptr:471952; -.
DR CTD; 30834; -.
DR VGNC; VGNC:11686; POLR1H.
DR eggNOG; KOG2907; Eukaryota.
DR GeneTree; ENSGT00390000008126; -.
DR HOGENOM; CLU_093932_1_2_1; -.
DR InParanoid; Q1XHV8; -.
DR OMA; EMQYHTL; -.
DR OrthoDB; 1456544at2759; -.
DR TreeFam; TF313881; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000017914; Expressed in testis and 21 other tissues.
DR GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006379; P:mRNA cleavage; IEA:InterPro.
DR GO; GO:0006363; P:termination of RNA polymerase I transcription; IBA:GO_Central.
DR CDD; cd10507; Zn-ribbon_RPA12; 1.
DR InterPro; IPR019761; DNA-dir_RNA_pol-M_15_CS.
DR InterPro; IPR012164; Rpa12/Rpb9/Rpc10/TFS.
DR InterPro; IPR034004; Zn_ribbon_RPA12_C.
DR InterPro; IPR001222; Znf_TFIIS.
DR PANTHER; PTHR11239; PTHR11239; 1.
DR Pfam; PF01096; TFIIS_C; 1.
DR PIRSF; PIRSF005586; RNApol_RpoM; 1.
DR SMART; SM00440; ZnF_C2C2; 1.
DR PROSITE; PS01030; RNA_POL_M_15KD; 1.
DR PROSITE; PS00466; ZF_TFIIS_1; 1.
DR PROSITE; PS51133; ZF_TFIIS_2; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Zinc; Zinc-finger.
FT CHAIN 1..126
FT /note="DNA-directed RNA polymerase I subunit RPA12"
FT /id="PRO_0000245340"
FT ZN_FING 20..41
FT /note="C4-type"
FT /evidence="ECO:0000255"
FT ZN_FING 83..123
FT /note="TFIIS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT BINDING 87
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT BINDING 90
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT BINDING 115
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT BINDING 118
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
SQ SEQUENCE 126 AA; 13904 MW; C678AC7132A91432 CRC64;
MSVMDLANTC SSFQSDLDFC SDCGSVLPLP GAQDTVTCIR CGFNINVRDF EGKVVKTSVV
FHQLGTAMPM SVEEGPECQG PVVDRRCPRC GHEGMAYHTR QMRSADEGQT VFYTCTNCKF
QEKEDS
