ID   RPA12_RAT               Reviewed;         123 AA.
AC   Q6MFY5;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=DNA-directed RNA polymerase I subunit RPA12 {ECO:0000305};
DE   AltName: Full=DNA-directed RNA polymerase I subunit H {ECO:0000250|UniProtKB:Q9P1U0};
DE   AltName: Full=Zinc ribbon domain-containing protein 1 {ECO:0000312|RGD:1303114};
GN   Name=Polr1h {ECO:0000250|UniProtKB:Q9P1U0};
GN   Synonyms=Znrd1 {ECO:0000312|RGD:1303114};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15060004; DOI=10.1101/gr.1987704;
RA   Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA   Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT   "The genomic sequence and comparative analysis of the rat major
RT   histocompatibility complex.";
RL   Genome Res. 14:631-639(2004).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Component of RNA polymerase I which synthesizes ribosomal RNA
CC       precursors.
CC   -!- SUBUNIT: Component of the RNA polymerase I (Pol I) complex consisting
CC       of at least 13 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P32529}.
CC   -!- SIMILARITY: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11
CC       RNA polymerase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX883052; CAE84062.1; -; Genomic_DNA.
DR   RefSeq; NP_001159772.1; NM_001166300.1.
DR   RefSeq; NP_998732.1; NM_213567.2.
DR   AlphaFoldDB; Q6MFY5; -.
DR   SMR; Q6MFY5; -.
DR   STRING; 10116.ENSRNOP00000001012; -.
DR   PaxDb; Q6MFY5; -.
DR   Ensembl; ENSRNOT00000001012; ENSRNOP00000001012; ENSRNOG00000000779.
DR   GeneID; 361784; -.
DR   KEGG; rno:361784; -.
DR   UCSC; RGD:1303114; rat.
DR   CTD; 30834; -.
DR   RGD; 1303114; Znrd1.
DR   eggNOG; KOG2907; Eukaryota.
DR   GeneTree; ENSGT00390000008126; -.
DR   HOGENOM; CLU_093932_1_2_1; -.
DR   InParanoid; Q6MFY5; -.
DR   OMA; EMQYHTL; -.
DR   OrthoDB; 1456544at2759; -.
DR   PhylomeDB; Q6MFY5; -.
DR   TreeFam; TF313881; -.
DR   Reactome; R-RNO-5250924; B-WICH complex positively regulates rRNA expression.
DR   Reactome; R-RNO-73762; RNA Polymerase I Transcription Initiation.
DR   Reactome; R-RNO-73772; RNA Polymerase I Promoter Escape.
DR   Reactome; R-RNO-73863; RNA Polymerase I Transcription Termination.
DR   PRO; PR:Q6MFY5; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000000779; Expressed in thymus and 20 other tissues.
DR   ExpressionAtlas; Q6MFY5; baseline and differential.
DR   Genevisible; Q6MFY5; RN.
DR   GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006379; P:mRNA cleavage; IEA:InterPro.
DR   GO; GO:0006363; P:termination of RNA polymerase I transcription; IBA:GO_Central.
DR   CDD; cd10507; Zn-ribbon_RPA12; 1.
DR   InterPro; IPR019761; DNA-dir_RNA_pol-M_15_CS.
DR   InterPro; IPR012164; Rpa12/Rpb9/Rpc10/TFS.
DR   InterPro; IPR034004; Zn_ribbon_RPA12_C.
DR   InterPro; IPR001222; Znf_TFIIS.
DR   PANTHER; PTHR11239; PTHR11239; 1.
DR   Pfam; PF01096; TFIIS_C; 1.
DR   PIRSF; PIRSF005586; RNApol_RpoM; 1.
DR   SMART; SM00440; ZnF_C2C2; 1.
DR   PROSITE; PS01030; RNA_POL_M_15KD; 1.
DR   PROSITE; PS00466; ZF_TFIIS_1; 1.
DR   PROSITE; PS51133; ZF_TFIIS_2; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Zinc; Zinc-finger.
FT   CHAIN           1..123
FT                   /note="DNA-directed RNA polymerase I subunit RPA12"
FT                   /id="PRO_0000121463"
FT   ZN_FING         17..38
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         80..120
FT                   /note="TFIIS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         84
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         87
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         112
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         115
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
SQ   SEQUENCE   123 AA;  13586 MW;  A0EB877E813C3431 CRC64;
     MELARPCSNF QSDLDFCPDC GSVLPLPGVQ DTVICPRCGF SIDVRDFGGK VVKTSVVFNK
     LGTVIPMSVD EGPESQGPVV DRRCSRCGHE GMAYYTRQMR SADEGQTVFY TCINCKFQEK
     EDS