RPA43_DICDI
ID RPA43_DICDI Reviewed; 356 AA.
AC Q55FA4;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Probable DNA-directed RNA polymerase I subunit RPA43;
GN Name=rpa43; ORFNames=DDB_G0268198;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Component of RNA polymerase I which synthesizes ribosomal RNA
CC precursors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase I (Pol I) complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- INDUCTION: Up-regulated by phagocytic stimuli.
CC {ECO:0000269|PubMed:18559084}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPA43 RNA polymerase subunit
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000003; EAL73552.1; -; Genomic_DNA.
DR RefSeq; XP_647629.1; XM_642537.1.
DR AlphaFoldDB; Q55FA4; -.
DR SMR; Q55FA4; -.
DR STRING; 44689.DDB0216290; -.
DR PaxDb; Q55FA4; -.
DR EnsemblProtists; EAL73552; EAL73552; DDB_G0268198.
DR GeneID; 8616444; -.
DR KEGG; ddi:DDB_G0268198; -.
DR dictyBase; DDB_G0268198; rpa43.
DR eggNOG; KOG4134; Eukaryota.
DR HOGENOM; CLU_779440_0_0_1; -.
DR InParanoid; Q55FA4; -.
DR OMA; CLVVGPH; -.
DR Reactome; R-DDI-73762; RNA Polymerase I Transcription Initiation.
DR Reactome; R-DDI-73772; RNA Polymerase I Promoter Escape.
DR PRO; PR:Q55FA4; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005736; C:RNA polymerase I complex; ISS:dictyBase.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; ISS:dictyBase.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR GO; GO:0006360; P:transcription by RNA polymerase I; ISS:dictyBase.
DR CDD; cd04328; RNAP_I_Rpa43_N; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.30.1490.120; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR036898; RNA_pol_Rpb7-like_N_sf.
DR InterPro; IPR041901; RNAP_I_Rpa43_N.
DR InterPro; IPR041178; RPA43_OB.
DR InterPro; IPR045113; Rpb7-like.
DR PANTHER; PTHR12709; PTHR12709; 1.
DR Pfam; PF17875; RPA43_OB; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
PE 2: Evidence at transcript level;
KW DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..356
FT /note="Probable DNA-directed RNA polymerase I subunit
FT RPA43"
FT /id="PRO_0000365595"
FT REGION 211..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 40319 MW; 05F5194F2245C8B3 CRC64;
MTSKIVSVNP LIKPVENCFE EMKVQLSLQL PPMDTQSLCS GTKSMLDRLV FKYKTELGGI
IISYYDVIHT DKEAKIFYDS PYLGMNIHVK FLVFKPFKDQ ILNGVVKRVS TTHISLLVFG
TISASIPKSN IPKSFAFDHS SNMFMNKQTK ATISVGTKIA FKVIDVSADR HNIGIQGDMT
DLTSTGIIGF DENQSLQFGS QYETPNKNVK NNKYNNNNNN NNNGNNNTTL INTENNNNIT
KFDDDSEKES EEEPKPIIIK EEPKIVSVKV ESKKVVVKEE EQKSSKKDKD IKKEKESKKR
KKDSSDESDE SEEDKKKKST KKEKESSSKK SSKKVKVESS SESSEDEKEK KKKKKK
