ID   RPA49_DICDI             Reviewed;         375 AA.
AC   Q54FE8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=DNA-directed RNA polymerase I subunit rpa49;
DE            Short=RNA polymerase I subunit A49;
DE   AltName: Full=DNA-directed RNA polymerase I subunit E;
GN   Name=polr1e; Synonyms=rpa49; ORFNames=DDB_G0290909;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase I (Pol I) complex consisting
CC       of at least 13 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase
CC       subunit family. {ECO:0000305}.
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DR   EMBL; AAFI02000172; EAL61970.1; -; Genomic_DNA.
DR   RefSeq; XP_635474.1; XM_630382.1.
DR   AlphaFoldDB; Q54FE8; -.
DR   SMR; Q54FE8; -.
DR   STRING; 44689.DDB0216301; -.
DR   PaxDb; Q54FE8; -.
DR   EnsemblProtists; EAL61970; EAL61970; DDB_G0290909.
DR   GeneID; 8627890; -.
DR   KEGG; ddi:DDB_G0290909; -.
DR   dictyBase; DDB_G0290909; rpa49.
DR   eggNOG; ENOG502SEKB; Eukaryota.
DR   HOGENOM; CLU_738577_0_0_1; -.
DR   InParanoid; Q54FE8; -.
DR   OMA; VASENWI; -.
DR   PhylomeDB; Q54FE8; -.
DR   Reactome; R-DDI-73762; RNA Polymerase I Transcription Initiation.
DR   Reactome; R-DDI-73772; RNA Polymerase I Promoter Escape.
DR   PRO; PR:Q54FE8; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005736; C:RNA polymerase I complex; ISS:dictyBase.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; ISS:dictyBase.
DR   GO; GO:0042790; P:nucleolar large rRNA transcription by RNA polymerase I; IBA:GO_Central.
DR   GO; GO:0001188; P:RNA polymerase I preinitiation complex assembly; IBA:GO_Central.
DR   GO; GO:0006360; P:transcription by RNA polymerase I; ISS:dictyBase.
DR   GO; GO:0006362; P:transcription elongation from RNA polymerase I promoter; IBA:GO_Central.
DR   InterPro; IPR009668; RNA_pol-assoc_fac_A49-like.
DR   PANTHER; PTHR14440; PTHR14440; 1.
DR   Pfam; PF06870; RNA_pol_I_A49; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..375
FT                   /note="DNA-directed RNA polymerase I subunit rpa49"
FT                   /id="PRO_0000327563"
SQ   SEQUENCE   375 AA;  43251 MW;  5041E70A02CE2BA8 CRC64;
     MSNLTVNVIE EKNLGDNKPC VLKFSQGLPP LSFIEKEPEF ISMSTKNKRH RVVLTNTDQL
     EYESEDKDSK YAKYAIGIFD KNTKQLKIVP TKIQTMNQSV IGYTLTLDSS SVISREERYD
     KIKKLADSFG SKITKKKMQK MEMENVENLD YEKTTKSIDA VKNELADIES NEKPFDLPDF
     DAETNDVRKI YNIEAILPPR IFFGLNHQPF LDIISKTSEA PSYLPEYFKD QLKRFEDIKD
     EEKVVYNCKL LTFMWYSMIL MKSKGGHEPL IKEGCTSEVI NFLVSIFGSK INHKKYNISQ
     DDKLKIYNYL AIFALKLEDF QITDIKSLAQ SLSLTSSSFE KHFTRVGCKV VRIGSEKRSV
     RLEAPLKLPK ARFSN