ID   RPA49_XENLA             Reviewed;         419 AA.
AC   Q6GLI9;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=DNA-directed RNA polymerase I subunit RPA49;
DE            Short=RNA polymerase I subunit A49;
DE   AltName: Full=DNA-directed RNA polymerase I subunit E;
DE   AltName: Full=RNA polymerase I-associated factor 1;
DE   AltName: Full=RNA polymerase I-associated factor 53;
GN   Name=polr1e; Synonyms=paf53, praf1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Component of RNA polymerase I which synthesizes ribosomal RNA
CC       precursors. Appears to be involved in the formation of the initiation
CC       complex at the promoter by mediating the interaction between Pol I and
CC       UBTF/UBF. {ECO:0000250|UniProtKB:Q9GZS1}.
CC   -!- SUBUNIT: Component of the RNA polymerase I (Pol I) complex consisting
CC       of at least 13 subunits. {ECO:0000250|UniProtKB:Q9GZS1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9GZS1}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase
CC       subunit family. {ECO:0000305}.
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DR   EMBL; BC074496; AAH74496.1; -; mRNA.
DR   RefSeq; NP_001086330.1; NM_001092861.1.
DR   AlphaFoldDB; Q6GLI9; -.
DR   SMR; Q6GLI9; -.
DR   BioGRID; 102922; 1.
DR   IntAct; Q6GLI9; 1.
DR   MaxQB; Q6GLI9; -.
DR   PRIDE; Q6GLI9; -.
DR   DNASU; 444759; -.
DR   GeneID; 444759; -.
DR   KEGG; xla:444759; -.
DR   CTD; 444759; -.
DR   Xenbase; XB-GENE-1003655; polr1e.L.
DR   OMA; DVYPFDE; -.
DR   OrthoDB; 800331at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 444759; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR009668; RNA_pol-assoc_fac_A49-like.
DR   PANTHER; PTHR14440; PTHR14440; 1.
DR   Pfam; PF06870; RNA_pol_I_A49; 1.
PE   2: Evidence at transcript level;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..419
FT                   /note="DNA-directed RNA polymerase I subunit RPA49"
FT                   /id="PRO_0000073958"
SQ   SEQUENCE   419 AA;  47367 MW;  06568428914ED7AB CRC64;
     MASRASWEYH GASQQSQGAL LVQFSNGTIQ SPESVNFTLY GNKDDKNPKT KRQKILAAET
     DRLNYVGNNF SSDTLKCSSL CRYFVGVLNK ETGKMEVYDA EQFKMQPILK SGMENELHTE
     DIVDQPTKSY REKVDALIES FGTNKQKRAL SSRKLNQVGS DILNKAMAKA AEEIIESRGT
     TELIKDAAEK REQDTSLFLP PCDFNADKPE NAYKFDNLIS PVEYAALETA SAALRNITSE
     GLQQMVEEKK SGLFVLQELH GLREIKDEKA LDHQARCLWY LDALIKLSQL RTVKRKDILT
     PECPSVVCWK LMKNFTVETY KNGRIQNAIS GTTKTKIVAY IIAIALHICD FQVDLTLLQR
     DMKLKESRIL EIAKVMGLKI KKRMMYSESS IEEGHKIGLL TIPLTVYKPS GGELKRKKM