RPAB1_ASHGO
ID RPAB1_ASHGO Reviewed; 215 AA.
AC Q757H7;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=DNA-directed RNA polymerases I, II, and III subunit RPABC1;
DE Short=RNA polymerases I, II, and III subunit ABC1;
GN Name=RPB5; OrderedLocusNames=AER036W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Common component of RNA polymerases I, II and III which synthesize
CC ribosomal RNA precursors, mRNA precursors and many functional non-
CC coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
CC Pol II is the central component of the basal RNA polymerase II
CC transcription machinery. Pols are composed of mobile elements that move
CC relative to each other. In Pol II, RPB5 is part of the lower jaw
CC surrounding the central large cleft and thought to grab the incoming
CC DNA template. Seems to be the major component in this process (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase I (Pol I), RNA polymerase II
CC (Pol II) and RNA polymerase III (Pol III) complexes consisting of at
CC least 14, 12 and 17 subunits, respectively. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase
CC subunit family. {ECO:0000305}.
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DR EMBL; AE016818; AAS52720.1; -; Genomic_DNA.
DR RefSeq; NP_984896.1; NM_210250.1.
DR AlphaFoldDB; Q757H7; -.
DR SMR; Q757H7; -.
DR STRING; 33169.AAS52720; -.
DR EnsemblFungi; AAS52720; AAS52720; AGOS_AER036W.
DR GeneID; 4621098; -.
DR KEGG; ago:AGOS_AER036W; -.
DR eggNOG; KOG3218; Eukaryota.
DR HOGENOM; CLU_058320_0_0_1; -.
DR InParanoid; Q757H7; -.
DR OMA; VRDRGYF; -.
DR Proteomes; UP000000591; Chromosome V.
DR GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR GO; GO:0005665; C:RNA polymerase II, core complex; IBA:GO_Central.
DR GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0001054; F:RNA polymerase I activity; IEA:EnsemblFungi.
DR GO; GO:0001055; F:RNA polymerase II activity; IEA:EnsemblFungi.
DR GO; GO:0001056; F:RNA polymerase III activity; IEA:EnsemblFungi.
DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:EnsemblFungi.
DR GO; GO:0042790; P:nucleolar large rRNA transcription by RNA polymerase I; IEA:EnsemblFungi.
DR GO; GO:0006363; P:termination of RNA polymerase I transcription; IEA:EnsemblFungi.
DR GO; GO:0006386; P:termination of RNA polymerase III transcription; IEA:EnsemblFungi.
DR GO; GO:0006362; P:transcription elongation from RNA polymerase I promoter; IEA:EnsemblFungi.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR GO; GO:0006361; P:transcription initiation from RNA polymerase I promoter; IEA:EnsemblFungi.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; IEA:EnsemblFungi.
DR GO; GO:0042797; P:tRNA transcription by RNA polymerase III; IEA:EnsemblFungi.
DR Gene3D; 3.40.1340.10; -; 1.
DR Gene3D; 3.90.940.20; -; 1.
DR HAMAP; MF_00025; RNApol_Rpo5_RPB5; 1.
DR InterPro; IPR014381; Arch_Rpo5/euc_Rpb5.
DR InterPro; IPR005571; RNA_pol_Rpb5_N.
DR InterPro; IPR036710; RNA_pol_Rpb5_N_sf.
DR InterPro; IPR000783; RNA_pol_subH/Rpb5_C.
DR InterPro; IPR020608; RNA_pol_subH/Rpb5_CS.
DR InterPro; IPR035913; RPB5-like_sf.
DR PANTHER; PTHR10535; PTHR10535; 1.
DR Pfam; PF01191; RNA_pol_Rpb5_C; 1.
DR Pfam; PF03871; RNA_pol_Rpb5_N; 1.
DR PIRSF; PIRSF000747; RPB5; 1.
DR SUPFAM; SSF53036; SSF53036; 1.
DR SUPFAM; SSF55287; SSF55287; 1.
DR PROSITE; PS01110; RNA_POL_H_23KD; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..215
FT /note="DNA-directed RNA polymerases I, II, and III subunit
FT RPABC1"
FT /id="PRO_0000146079"
SQ SEQUENCE 215 AA; 24978 MW; 3F6A9BA133025F16 CRC64;
MDQDNERNVS RLWRAFRTVK EMVRDRGYFI TQEEVDLSLE DFKAKYCDSM GRPQRKMMSF
QSNPTEETLK KSPNMGSVWV EFCDEPSVGI KTMKNFVIHI GEKNFQTGIF IYQNGITPSA
LKLLPSVAPA TIETFNETAL VVNITHHELV PKHIKLSDEE KKELLKRYRL KESQLPRIQR
MDPVALYLGL KRGEVVKIIR KSETSGRYAS YRICL
