ID   RPAB1_CAEEL             Reviewed;         211 AA.
AC   Q9N5K2;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=DNA-directed RNA polymerases I, II, and III subunit RPABC1;
DE            Short=RNA polymerases I, II, and III subunit ABC1;
DE   AltName: Full=RPB5 homolog;
GN   Name=rpb-5; ORFNames=H27M09.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Common component of RNA polymerases I, II and III which synthesize
CC       ribosomal RNA precursors, mRNA precursors and many functional non-
CC       coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
CC       Pol II is the central component of the basal RNA polymerase II
CC       transcription machinery. Pols are composed of mobile elements that move
CC       relative to each other. In Pol II, RPB5 is part of the lower jaw
CC       surrounding the central large cleft and thought to grab the incoming
CC       DNA template. Seems to be the major component in this process (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase I (Pol I), RNA polymerase II
CC       (Pol II) and RNA polymerase III (Pol III) complexes consisting of at
CC       least 13, 12 and 17 subunits, respectively. In RNA Pol II, this subunit
CC       is present in 2-fold molar excess over the other subunits (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase
CC       subunit family. {ECO:0000305}.
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DR   EMBL; FO081567; CCD72467.1; -; Genomic_DNA.
DR   RefSeq; NP_491961.1; NM_059560.3.
DR   AlphaFoldDB; Q9N5K2; -.
DR   SMR; Q9N5K2; -.
DR   BioGRID; 37858; 29.
DR   IntAct; Q9N5K2; 1.
DR   STRING; 6239.H27M09.2; -.
DR   EPD; Q9N5K2; -.
DR   PaxDb; Q9N5K2; -.
DR   PeptideAtlas; Q9N5K2; -.
DR   EnsemblMetazoa; H27M09.2.1; H27M09.2.1; WBGene00019246.
DR   GeneID; 172412; -.
DR   KEGG; cel:CELE_H27M09.2; -.
DR   CTD; 172412; -.
DR   WormBase; H27M09.2; CE23831; WBGene00019246; rpb-5.
DR   eggNOG; KOG3218; Eukaryota.
DR   GeneTree; ENSGT00390000013841; -.
DR   HOGENOM; CLU_058320_0_1_1; -.
DR   InParanoid; Q9N5K2; -.
DR   OMA; VRDRGYF; -.
DR   OrthoDB; 1255823at2759; -.
DR   PhylomeDB; Q9N5K2; -.
DR   Reactome; R-CEL-112382; Formation of RNA Pol II elongation complex.
DR   Reactome; R-CEL-113418; Formation of the Early Elongation Complex.
DR   Reactome; R-CEL-5578749; Transcriptional regulation by small RNAs.
DR   Reactome; R-CEL-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-CEL-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-CEL-6782135; Dual incision in TC-NER.
DR   Reactome; R-CEL-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-CEL-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR   Reactome; R-CEL-6803529; FGFR2 alternative splicing.
DR   Reactome; R-CEL-6807505; RNA polymerase II transcribes snRNA genes.
DR   Reactome; R-CEL-72086; mRNA Capping.
DR   Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-CEL-72165; mRNA Splicing - Minor Pathway.
DR   Reactome; R-CEL-73762; RNA Polymerase I Transcription Initiation.
DR   Reactome; R-CEL-73772; RNA Polymerase I Promoter Escape.
DR   Reactome; R-CEL-73776; RNA Polymerase II Promoter Escape.
DR   Reactome; R-CEL-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR   Reactome; R-CEL-75953; RNA Polymerase II Transcription Initiation.
DR   Reactome; R-CEL-75955; RNA Polymerase II Transcription Elongation.
DR   Reactome; R-CEL-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR   Reactome; R-CEL-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR   Reactome; R-CEL-9018519; Estrogen-dependent gene expression.
DR   PRO; PR:Q9N5K2; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00019246; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR   GO; GO:0005665; C:RNA polymerase II, core complex; IBA:GO_Central.
DR   GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.40.1340.10; -; 1.
DR   Gene3D; 3.90.940.20; -; 1.
DR   HAMAP; MF_00025; RNApol_Rpo5_RPB5; 1.
DR   InterPro; IPR014381; Arch_Rpo5/euc_Rpb5.
DR   InterPro; IPR005571; RNA_pol_Rpb5_N.
DR   InterPro; IPR036710; RNA_pol_Rpb5_N_sf.
DR   InterPro; IPR000783; RNA_pol_subH/Rpb5_C.
DR   InterPro; IPR020608; RNA_pol_subH/Rpb5_CS.
DR   InterPro; IPR035913; RPB5-like_sf.
DR   PANTHER; PTHR10535; PTHR10535; 1.
DR   Pfam; PF01191; RNA_pol_Rpb5_C; 1.
DR   Pfam; PF03871; RNA_pol_Rpb5_N; 1.
DR   PIRSF; PIRSF000747; RPB5; 1.
DR   SUPFAM; SSF53036; SSF53036; 1.
DR   SUPFAM; SSF55287; SSF55287; 1.
DR   PROSITE; PS01110; RNA_POL_H_23KD; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..211
FT                   /note="DNA-directed RNA polymerases I, II, and III subunit
FT                   RPABC1"
FT                   /id="PRO_0000146078"
SQ   SEQUENCE   211 AA;  24348 MW;  5DD4C49A6F3B6AE2 CRC64;
     MADDELETYR LWRIRKTVLQ MVHDRGYLVA QDELDQPLET FKVQYGDRPS EKKPARSDLT
     ILVAHNDDPA DQMFVFFPED AKIGIKTIKA ICQQMQEQNI SRAIIVVQTG MTPSAKQSIG
     DMAPKYMLEH FLEAELMVNI TEHELVPEHV VMTAEEKAEL LARYKLKDSQ LPRIQQCDPV
     ARYFGLRRGQ VVKIIRPSET AGRYITYRLV V