ID   RPAB1_DICDI             Reviewed;         197 AA.
AC   Q54EH2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=DNA-directed RNA polymerases I, II, and III subunit rpabc1;
DE            Short=RNA polymerases I, II, and III subunit ABC1;
DE   AltName: Full=RPB5 homolog;
GN   Name=polr2e; Synonyms=rpb5; ORFNames=DDB_G0291636;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Common component of RNA polymerases I, II and III which synthesize
CC       ribosomal RNA precursors, mRNA precursors and many functional non-
CC       coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
CC       Pol II is the central component of the basal RNA polymerase II
CC       transcription machinery. Pols are composed of mobile elements that move
CC       relative to each other. In Pol II, RPB5 is part of the lower jaw
CC       surrounding the central large cleft and thought to grab the incoming
CC       DNA template. Seems to be the major component in this process (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase I (Pol I), RNA polymerase II
CC       (Pol II) and RNA polymerase III (Pol III) complexes consisting of at
CC       least 13, 12 and 17 subunits, respectively. In RNA Pol II, this subunit
CC       is present in 2-fold molar excess over the other subunits (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase
CC       subunit family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL61802.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000177; EAL61802.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_635268.1; XM_630176.1.
DR   AlphaFoldDB; Q54EH2; -.
DR   SMR; Q54EH2; -.
DR   STRING; 44689.DDB0216287; -.
DR   PaxDb; Q54EH2; -.
DR   EnsemblProtists; EAL61802; EAL61802; DDB_G0291636.
DR   GeneID; 8628212; -.
DR   KEGG; ddi:DDB_G0291636; -.
DR   dictyBase; DDB_G0291636; rpb5.
DR   eggNOG; KOG3218; Eukaryota.
DR   InParanoid; Q54EH2; -.
DR   PhylomeDB; Q54EH2; -.
DR   Reactome; R-DDI-113418; Formation of the Early Elongation Complex.
DR   Reactome; R-DDI-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-DDI-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-DDI-6782135; Dual incision in TC-NER.
DR   Reactome; R-DDI-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-DDI-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR   Reactome; R-DDI-6803529; FGFR2 alternative splicing.
DR   Reactome; R-DDI-6807505; RNA polymerase II transcribes snRNA genes.
DR   Reactome; R-DDI-72086; mRNA Capping.
DR   Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-DDI-72165; mRNA Splicing - Minor Pathway.
DR   Reactome; R-DDI-73762; RNA Polymerase I Transcription Initiation.
DR   Reactome; R-DDI-73772; RNA Polymerase I Promoter Escape.
DR   Reactome; R-DDI-73776; RNA Polymerase II Promoter Escape.
DR   Reactome; R-DDI-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR   Reactome; R-DDI-75953; RNA Polymerase II Transcription Initiation.
DR   Reactome; R-DDI-75955; RNA Polymerase II Transcription Elongation.
DR   Reactome; R-DDI-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR   Reactome; R-DDI-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR   Reactome; R-DDI-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR   Reactome; R-DDI-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR   Reactome; R-DDI-9018519; Estrogen-dependent gene expression.
DR   PRO; PR:Q54EH2; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005736; C:RNA polymerase I complex; ISS:dictyBase.
DR   GO; GO:0005665; C:RNA polymerase II, core complex; ISS:dictyBase.
DR   GO; GO:0005666; C:RNA polymerase III complex; ISS:dictyBase.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; ISS:dictyBase.
DR   GO; GO:0006360; P:transcription by RNA polymerase I; ISS:dictyBase.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:dictyBase.
DR   GO; GO:0006383; P:transcription by RNA polymerase III; ISS:dictyBase.
DR   Gene3D; 3.40.1340.10; -; 1.
DR   Gene3D; 3.90.940.20; -; 1.
DR   HAMAP; MF_00025; RNApol_Rpo5_RPB5; 1.
DR   InterPro; IPR014381; Arch_Rpo5/euc_Rpb5.
DR   InterPro; IPR005571; RNA_pol_Rpb5_N.
DR   InterPro; IPR036710; RNA_pol_Rpb5_N_sf.
DR   InterPro; IPR000783; RNA_pol_subH/Rpb5_C.
DR   InterPro; IPR020608; RNA_pol_subH/Rpb5_CS.
DR   InterPro; IPR035913; RPB5-like_sf.
DR   PANTHER; PTHR10535; PTHR10535; 1.
DR   Pfam; PF01191; RNA_pol_Rpb5_C; 1.
DR   Pfam; PF03871; RNA_pol_Rpb5_N; 1.
DR   PIRSF; PIRSF000747; RPB5; 1.
DR   SUPFAM; SSF53036; SSF53036; 1.
DR   SUPFAM; SSF55287; SSF55287; 1.
DR   PROSITE; PS01110; RNA_POL_H_23KD; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..197
FT                   /note="DNA-directed RNA polymerases I, II, and III subunit
FT                   rpabc1"
FT                   /id="PRO_0000329306"
SQ   SEQUENCE   197 AA;  23198 MW;  07FF789A07A10AFD CRC64;
     MEDINRLLQI RKTVLQMLSD REYIITAYEQ EYPRESFVSR ENLTMYCVKK DDPTDSIYVF
     FPDTPKVGVT QIKKYVDIMK DRQANRAIIV VQQNITPFAK QALAEFSQEK KITLEQFNEA
     ELLVNITHHQ LVPKHILLTK EEKLELLTRY KMKESQLPRI QTNDPVARYY GLSRGHVVKI
     VRPSETAGRY ITYRLCV