RPAB1_KLULA
ID RPAB1_KLULA Reviewed; 215 AA.
AC Q6CJ62;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=DNA-directed RNA polymerases I, II, and III subunit RPABC1;
DE Short=RNA polymerases I, II, and III subunit ABC1;
GN Name=RPB5; OrderedLocusNames=KLLA0F21098g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Common component of RNA polymerases I, II and III which synthesize
CC ribosomal RNA precursors, mRNA precursors and many functional non-
CC coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
CC Pol II is the central component of the basal RNA polymerase II
CC transcription machinery. Pols are composed of mobile elements that move
CC relative to each other. In Pol II, RPB5 is part of the lower jaw
CC surrounding the central large cleft and thought to grab the incoming
CC DNA template. Seems to be the major component in this process (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase I (Pol I), RNA polymerase II
CC (Pol II) and RNA polymerase III (Pol III) complexes consisting of at
CC least 14, 12 and 17 subunits, respectively. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase
CC subunit family. {ECO:0000305}.
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DR EMBL; CR382126; CAG98735.1; -; Genomic_DNA.
DR RefSeq; XP_456027.1; XM_456027.1.
DR AlphaFoldDB; Q6CJ62; -.
DR SMR; Q6CJ62; -.
DR STRING; 28985.XP_456027.1; -.
DR EnsemblFungi; CAG98735; CAG98735; KLLA0_F21098g.
DR GeneID; 2895462; -.
DR KEGG; kla:KLLA0_F21098g; -.
DR eggNOG; KOG3218; Eukaryota.
DR HOGENOM; CLU_058320_0_0_1; -.
DR InParanoid; Q6CJ62; -.
DR OMA; VRDRGYF; -.
DR Proteomes; UP000000598; Chromosome F.
DR GO; GO:0005736; C:RNA polymerase I complex; IEA:EnsemblFungi.
DR GO; GO:0005665; C:RNA polymerase II, core complex; IEA:EnsemblFungi.
DR GO; GO:0005666; C:RNA polymerase III complex; IEA:EnsemblFungi.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0001054; F:RNA polymerase I activity; IEA:EnsemblFungi.
DR GO; GO:0001055; F:RNA polymerase II activity; IEA:EnsemblFungi.
DR GO; GO:0001056; F:RNA polymerase III activity; IEA:EnsemblFungi.
DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:EnsemblFungi.
DR GO; GO:0042790; P:nucleolar large rRNA transcription by RNA polymerase I; IEA:EnsemblFungi.
DR GO; GO:0006363; P:termination of RNA polymerase I transcription; IEA:EnsemblFungi.
DR GO; GO:0006386; P:termination of RNA polymerase III transcription; IEA:EnsemblFungi.
DR GO; GO:0006362; P:transcription elongation from RNA polymerase I promoter; IEA:EnsemblFungi.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR GO; GO:0006361; P:transcription initiation from RNA polymerase I promoter; IEA:EnsemblFungi.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; IEA:EnsemblFungi.
DR GO; GO:0042797; P:tRNA transcription by RNA polymerase III; IEA:EnsemblFungi.
DR Gene3D; 3.40.1340.10; -; 1.
DR Gene3D; 3.90.940.20; -; 1.
DR HAMAP; MF_00025; RNApol_Rpo5_RPB5; 1.
DR InterPro; IPR014381; Arch_Rpo5/euc_Rpb5.
DR InterPro; IPR005571; RNA_pol_Rpb5_N.
DR InterPro; IPR036710; RNA_pol_Rpb5_N_sf.
DR InterPro; IPR000783; RNA_pol_subH/Rpb5_C.
DR InterPro; IPR020608; RNA_pol_subH/Rpb5_CS.
DR InterPro; IPR035913; RPB5-like_sf.
DR PANTHER; PTHR10535; PTHR10535; 1.
DR Pfam; PF01191; RNA_pol_Rpb5_C; 1.
DR Pfam; PF03871; RNA_pol_Rpb5_N; 1.
DR PIRSF; PIRSF000747; RPB5; 1.
DR SUPFAM; SSF53036; SSF53036; 1.
DR SUPFAM; SSF55287; SSF55287; 1.
DR PROSITE; PS01110; RNA_POL_H_23KD; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..215
FT /note="DNA-directed RNA polymerases I, II, and III subunit
FT RPABC1"
FT /id="PRO_0000146082"
SQ SEQUENCE 215 AA; 24969 MW; D468F531C3BB3D34 CRC64;
MDQEQERNIS RLWRAFKTVK EMVRDRGYFI TQEEIDLSLE DFKAKYCDSM GKPQRKMMSF
QSNPTEESIE KFPEMGSLWV EFCDEASVGV KTMKNFVVHI TEKNFQTGIF IYQSGITPSA
NKILPTAAPA VIETFPEASL VVNITHHELV PKHIRLSEAE KKELLKRYRL KESQLPRIQR
MDPVALYLGL KRGEVIKIIR KSETSGRYAS YRICL
