ID   RPAB3_CAEBR             Reviewed;         148 AA.
AC   A8XT81;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 {ECO:0000250|UniProtKB:Q19826};
DE            Short=RNA polymerases I, II, and III subunit ABC3 {ECO:0000250|UniProtKB:Q19826};
DE   AltName: Full=RNA polymerase B subunit 8;
DE            Short=RPB8;
GN   Name=rpb-8 {ECO:0000312|EMBL:CAP35684.1}; ORFNames=CBG18189;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP35684.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000312|EMBL:CAP35684.1};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Common component of RNA polymerases I, II and III which synthesize
CC       ribosomal RNA precursors, mRNA precursors and many functional non-
CC       coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively
CC       (By similarity). {ECO:0000250|UniProtKB:P52434}.
CC   -!- SUBUNIT: Component of the RNA polymerase I (Pol I), RNA polymerase II
CC       (Pol II) and RNA polymerase III (Pol III) complexes consisting of at
CC       least 13, 12 and 17 subunits, respectively. Directly interacts with
CC       POLR2A (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P52434}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPB8 RNA polymerase subunit
CC       family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE600936; CAP35684.1; -; Genomic_DNA.
DR   RefSeq; XP_002642215.1; XM_002642169.1.
DR   AlphaFoldDB; A8XT81; -.
DR   SMR; A8XT81; -.
DR   STRING; 6238.CBG18189; -.
DR   EnsemblMetazoa; CBG18189.1; CBG18189.1; WBGene00037654.
DR   GeneID; 8584211; -.
DR   KEGG; cbr:CBG_18189; -.
DR   CTD; 8584211; -.
DR   WormBase; CBG18189; CBP19241; WBGene00037654; Cbr-rpb-8.
DR   eggNOG; KOG3400; Eukaryota.
DR   HOGENOM; CLU_103864_1_1_1; -.
DR   InParanoid; A8XT81; -.
DR   OMA; TINAYVS; -.
DR   OrthoDB; 1504067at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR   GO; GO:0005665; C:RNA polymerase II, core complex; IBA:GO_Central.
DR   GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR005570; RNA_pol_Rpb8.
DR   PANTHER; PTHR10917; PTHR10917; 1.
DR   Pfam; PF03870; RNA_pol_Rpb8; 1.
DR   PIRSF; PIRSF000779; RNA_pol_Rpb8; 1.
DR   SMART; SM00658; RPOL8c; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
PE   3: Inferred from homology;
KW   DNA-binding; DNA-directed RNA polymerase; Nucleus; Reference proteome;
KW   Transcription.
FT   CHAIN           1..148
FT                   /note="Probable DNA-directed RNA polymerases I, II, and III
FT                   subunit RPABC3"
FT                   /id="PRO_0000365632"
FT   REGION          16..40
FT                   /note="Non-specific ssDNA binding"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   148 AA;  17004 MW;  C2DA4ACA92A2EC21 CRC64;
     MAGIIFDDMF SVKSVDPDGK KFDRVSRYFC DAESFKMELI IDINSQIYPL KQNDKFRLVL
     ATTLREDGLA DEGEYDPKAE YPRIKQYEYV MYGKVYRLED DDSGTDGGQL AAYASFGGLL
     MRLKGEAINL HGFEVDMNLY LLMKKTDF