RPAB3_CAEEL
ID RPAB3_CAEEL Reviewed; 148 AA.
AC Q19826;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3;
DE Short=RNA polymerases I, II, and III subunit ABC3;
DE AltName: Full=RNA polymerase B subunit 8;
DE Short=RPB8;
DE AltName: Full=RPB17;
GN Name=rpb-8; ORFNames=F26F4.11;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Common component of RNA polymerases I, II and III which synthesize
CC ribosomal RNA precursors, mRNA precursors and many functional non-
CC coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase I (Pol I), RNA polymerase II
CC (Pol II) and RNA polymerase III (Pol III) complexes consisting of at
CC least 13, 12 and 17 subunits, respectively. Directly interacts with
CC POLR2A (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q19826; Q20628: cdd-2; NbExp=3; IntAct=EBI-320556, EBI-320562;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPB8 RNA polymerase subunit
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080682; CCD65759.1; -; Genomic_DNA.
DR PIR; T16177; T16177.
DR RefSeq; NP_498036.1; NM_065635.3.
DR AlphaFoldDB; Q19826; -.
DR SMR; Q19826; -.
DR BioGRID; 40894; 30.
DR DIP; DIP-26518N; -.
DR IntAct; Q19826; 2.
DR STRING; 6239.F26F4.11; -.
DR EPD; Q19826; -.
DR PaxDb; Q19826; -.
DR PeptideAtlas; Q19826; -.
DR EnsemblMetazoa; F26F4.11.1; F26F4.11.1; WBGene00017830.
DR GeneID; 175660; -.
DR KEGG; cel:CELE_F26F4.11; -.
DR CTD; 175660; -.
DR WormBase; F26F4.11; CE04448; WBGene00017830; rpb-8.
DR eggNOG; KOG3400; Eukaryota.
DR GeneTree; ENSGT00390000018195; -.
DR HOGENOM; CLU_103864_1_1_1; -.
DR InParanoid; Q19826; -.
DR OMA; TINAYVS; -.
DR OrthoDB; 1504067at2759; -.
DR PhylomeDB; Q19826; -.
DR Reactome; R-CEL-112382; Formation of RNA Pol II elongation complex.
DR Reactome; R-CEL-113418; Formation of the Early Elongation Complex.
DR Reactome; R-CEL-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-CEL-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-CEL-6781823; Formation of TC-NER Pre-Incision Complex.
DR Reactome; R-CEL-6782135; Dual incision in TC-NER.
DR Reactome; R-CEL-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR Reactome; R-CEL-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR Reactome; R-CEL-6803529; FGFR2 alternative splicing.
DR Reactome; R-CEL-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-CEL-72086; mRNA Capping.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72165; mRNA Splicing - Minor Pathway.
DR Reactome; R-CEL-73762; RNA Polymerase I Transcription Initiation.
DR Reactome; R-CEL-73772; RNA Polymerase I Promoter Escape.
DR Reactome; R-CEL-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-CEL-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-CEL-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-CEL-75955; RNA Polymerase II Transcription Elongation.
DR Reactome; R-CEL-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Reactome; R-CEL-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR Reactome; R-CEL-9018519; Estrogen-dependent gene expression.
DR PRO; PR:Q19826; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00017830; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR GO; GO:0005665; C:RNA polymerase II, core complex; IBA:GO_Central.
DR GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR005570; RNA_pol_Rpb8.
DR PANTHER; PTHR10917; PTHR10917; 1.
DR Pfam; PF03870; RNA_pol_Rpb8; 1.
DR PIRSF; PIRSF000779; RNA_pol_Rpb8; 1.
DR SMART; SM00658; RPOL8c; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
PE 1: Evidence at protein level;
KW DNA-binding; DNA-directed RNA polymerase; Nucleus; Reference proteome;
KW Transcription.
FT CHAIN 1..148
FT /note="Probable DNA-directed RNA polymerases I, II, and III
FT subunit RPABC3"
FT /id="PRO_0000073999"
FT REGION 16..40
FT /note="Non-specific ssDNA binding"
FT /evidence="ECO:0000250"
SQ SEQUENCE 148 AA; 17011 MW; 3CEE2754FBB44BF1 CRC64;
MAGIIFDDMF KVKSVDPDGK KFDRVSRYFC DAESFKMELI IDINSQIYPL KQNDKVRLVL
ATTLREDGLA DEGEYDPKAE YPRIKQYEYV MYGKVYRLED DDTGTDGGKL AAYASFGGLL
MRLKGEAINL HGFEVDMNLY LLMKKTDF
