ID   RPAB4_BOVIN             Reviewed;          58 AA.
AC   Q3ZBC0;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=DNA-directed RNA polymerases I, II, and III subunit RPABC4;
DE            Short=RNA polymerases I, II, and III subunit ABC4;
DE   AltName: Full=DNA-directed RNA polymerase II subunit K;
GN   Name=POLR2K;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Common component of RNA polymerases I, II and III which synthesize
CC       ribosomal RNA precursors, mRNA precursors and many functional non-
CC       coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase I (Pol I), RNA polymerase II
CC       (Pol II) and RNA polymerase III (Pol III) complexes consisting of at
CC       least 13, 12 and 17 subunits, respectively. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA
CC       polymerase subunit family. {ECO:0000305}.
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DR   EMBL; BC103450; AAI03451.1; -; mRNA.
DR   RefSeq; NP_001032712.1; NM_001037623.3.
DR   RefSeq; NP_001290464.1; NM_001303535.1.
DR   RefSeq; NP_001290465.1; NM_001303536.1.
DR   RefSeq; XP_015321795.1; XM_015466309.1.
DR   RefSeq; XP_015329927.1; XM_015474441.1.
DR   PDB; 5FLM; EM; 3.40 A; L=1-58.
DR   PDB; 5OIK; EM; 3.70 A; L=1-58.
DR   PDBsum; 5FLM; -.
DR   PDBsum; 5OIK; -.
DR   AlphaFoldDB; Q3ZBC0; -.
DR   SMR; Q3ZBC0; -.
DR   DIP; DIP-61197N; -.
DR   IntAct; Q3ZBC0; 2.
DR   STRING; 9913.ENSBTAP00000030490; -.
DR   PaxDb; Q3ZBC0; -.
DR   Ensembl; ENSBTAT00000030510; ENSBTAP00000030490; ENSBTAG00000022539.
DR   GeneID; 614776; -.
DR   KEGG; bta:614776; -.
DR   CTD; 5440; -.
DR   VEuPathDB; HostDB:ENSBTAG00000022539; -.
DR   VGNC; VGNC:57357; POLR2K.
DR   eggNOG; KOG3507; Eukaryota.
DR   GeneTree; ENSGT00390000008918; -.
DR   HOGENOM; CLU_179456_1_0_1; -.
DR   InParanoid; Q3ZBC0; -.
DR   OMA; VIRCREC; -.
DR   OrthoDB; 1620152at2759; -.
DR   TreeFam; TF103045; -.
DR   Reactome; R-BTA-113418; Formation of the Early Elongation Complex.
DR   Reactome; R-BTA-5250924; B-WICH complex positively regulates rRNA expression.
DR   Reactome; R-BTA-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-BTA-73762; RNA Polymerase I Transcription Initiation.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000022539; Expressed in biceps femoris and 105 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR   GO; GO:0005665; C:RNA polymerase II, core complex; ISS:UniProtKB.
DR   GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR006591; RNAP_P/RPABC4.
DR   InterPro; IPR039747; RPABC4.
DR   InterPro; IPR029040; RPABC4/Spt4.
DR   PANTHER; PTHR12056; PTHR12056; 1.
DR   Pfam; PF03604; DNA_RNApol_7kD; 1.
DR   SMART; SM00659; RPOLCX; 1.
DR   SUPFAM; SSF63393; SSF63393; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-directed RNA polymerase; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Zinc; Zinc-finger.
FT   CHAIN           1..58
FT                   /note="DNA-directed RNA polymerases I, II, and III subunit
FT                   RPABC4"
FT                   /id="PRO_0000291378"
FT   ZN_FING         19..39
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   BINDING         19
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         22
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         36
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         39
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   STRAND          16..22
FT                   /evidence="ECO:0007829|PDB:5FLM"
FT   TURN            37..39
FT                   /evidence="ECO:0007829|PDB:5FLM"
FT   STRAND          54..56
FT                   /evidence="ECO:0007829|PDB:5FLM"
SQ   SEQUENCE   58 AA;  7004 MW;  239BA3A67416F02C CRC64;
     MDTQKDVQPP KQQPMIYICG ECHTENEIKS RDPIRCRECG YRIMYKKRTK RLVVFDAR