RPAB4_MOUSE
ID RPAB4_MOUSE Reviewed; 58 AA.
AC Q63871;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=DNA-directed RNA polymerases I, II, and III subunit RPABC4;
DE Short=RNA polymerases I, II, and III subunit ABC4;
DE AltName: Full=DNA-directed RNA polymerase II subunit K;
DE AltName: Full=Metallothionein-I gene transcription activator;
DE AltName: Full=RPB10alpha;
GN Name=Polr2k; Synonyms=Mt1a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8329119; DOI=10.1089/dna.1993.12.517;
RA Xu C.;
RT "cDNA cloning of a mouse factor that activates transcription from a metal
RT response element of the mouse metallothionein-I gene in yeast.";
RL DNA Cell Biol. 12:517-525(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Common component of RNA polymerases I, II and III which synthesize
CC ribosomal RNA precursors, mRNA precursors and many functional non-
CC coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively
CC (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Factor that activates expression from a metal response
CC element of the mouse metallothionein-I gene.
CC -!- SUBUNIT: Component of the RNA polymerase I (Pol I), RNA polymerase II
CC (Pol II) and RNA polymerase III (Pol III) complexes consisting of at
CC least 13, 12 and 17 subunits, respectively. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA
CC polymerase subunit family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB27565.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; S63758; AAB27565.2; ALT_INIT; mRNA.
DR EMBL; BC028543; AAH28543.1; -; mRNA.
DR CCDS; CCDS56980.1; -.
DR RefSeq; NP_075616.2; NM_023127.3.
DR AlphaFoldDB; Q63871; -.
DR SMR; Q63871; -.
DR STRING; 10090.ENSMUSP00000051968; -.
DR PhosphoSitePlus; Q63871; -.
DR MaxQB; Q63871; -.
DR PaxDb; Q63871; -.
DR PRIDE; Q63871; -.
DR ProteomicsDB; 262700; -.
DR DNASU; 17749; -.
DR Ensembl; ENSMUST00000180159; ENSMUSP00000136975; ENSMUSG00000045996.
DR GeneID; 17749; -.
DR KEGG; mmu:17749; -.
DR UCSC; uc007vml.2; mouse.
DR CTD; 5440; -.
DR MGI; MGI:102725; Polr2k.
DR VEuPathDB; HostDB:ENSMUSG00000045996; -.
DR eggNOG; KOG3507; Eukaryota.
DR GeneTree; ENSGT00390000008918; -.
DR HOGENOM; CLU_179456_1_0_1; -.
DR InParanoid; Q63871; -.
DR PhylomeDB; Q63871; -.
DR Reactome; R-MMU-112382; Formation of RNA Pol II elongation complex.
DR Reactome; R-MMU-113418; Formation of the Early Elongation Complex.
DR Reactome; R-MMU-5250924; B-WICH complex positively regulates rRNA expression.
DR Reactome; R-MMU-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-MMU-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-MMU-6781823; Formation of TC-NER Pre-Incision Complex.
DR Reactome; R-MMU-6782135; Dual incision in TC-NER.
DR Reactome; R-MMU-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR Reactome; R-MMU-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR Reactome; R-MMU-6803529; FGFR2 alternative splicing.
DR Reactome; R-MMU-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-MMU-72086; mRNA Capping.
DR Reactome; R-MMU-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-MMU-72165; mRNA Splicing - Minor Pathway.
DR Reactome; R-MMU-72203; Processing of Capped Intron-Containing Pre-mRNA.
DR Reactome; R-MMU-73762; RNA Polymerase I Transcription Initiation.
DR Reactome; R-MMU-73772; RNA Polymerase I Promoter Escape.
DR Reactome; R-MMU-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-MMU-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-MMU-73863; RNA Polymerase I Transcription Termination.
DR Reactome; R-MMU-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-MMU-75955; RNA Polymerase II Transcription Elongation.
DR Reactome; R-MMU-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Reactome; R-MMU-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-MMU-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR Reactome; R-MMU-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR Reactome; R-MMU-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR Reactome; R-MMU-9018519; Estrogen-dependent gene expression.
DR BioGRID-ORCS; 17749; 7 hits in 37 CRISPR screens.
DR ChiTaRS; Polr2k; mouse.
DR PRO; PR:Q63871; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q63871; protein.
DR Bgee; ENSMUSG00000045996; Expressed in embryonic facial prominence and 80 other tissues.
DR ExpressionAtlas; Q63871; baseline and differential.
DR Genevisible; Q63871; MM.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR GO; GO:0005665; C:RNA polymerase II, core complex; ISS:UniProtKB.
DR GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IDA:MGI.
DR InterPro; IPR006591; RNAP_P/RPABC4.
DR InterPro; IPR039747; RPABC4.
DR InterPro; IPR029040; RPABC4/Spt4.
DR PANTHER; PTHR12056; PTHR12056; 1.
DR Pfam; PF03604; DNA_RNApol_7kD; 1.
DR SMART; SM00659; RPOLCX; 1.
DR SUPFAM; SSF63393; SSF63393; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Zinc; Zinc-finger.
FT CHAIN 1..58
FT /note="DNA-directed RNA polymerases I, II, and III subunit
FT RPABC4"
FT /id="PRO_0000159751"
FT ZN_FING 19..39
FT /note="C4-type"
FT /evidence="ECO:0000255"
FT BINDING 19
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 22
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 36
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 39
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
SQ SEQUENCE 58 AA; 6974 MW; D69BB6B37416F036 CRC64;
MDAQKDVQPP KQQPMIYICG ECHTENEIKS RDPIRCRECG YRIMYKKRTK RLVVFDAR
