RPAB5_BOVIN
ID RPAB5_BOVIN Reviewed; 67 AA.
AC Q32P78;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=DNA-directed RNA polymerases I, II, and III subunit RPABC5;
DE Short=RNA polymerases I, II, and III subunit ABC5;
DE AltName: Full=DNA-directed RNA polymerase III subunit L;
GN Name=POLR2L;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Common component of RNA polymerases I, II and III which synthesize
CC ribosomal RNA precursors, mRNA precursors and many functional non-
CC coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.
CC Pol II is the central component of the basal RNA polymerase II
CC transcription machinery. Pols are composed of mobile elements that move
CC relative to each other. In Pol II, POLR2L/RBP10 is part of the core
CC element with the central large cleft (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase I (Pol I), RNA polymerase II
CC (Pol II) and RNA polymerase III (Pol III) complexes consisting of at
CC least 13, 12 and 17 subunits, respectively. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA
CC polymerase subunit family. {ECO:0000305}.
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DR EMBL; BC108227; AAI08228.1; -; mRNA.
DR RefSeq; NP_001107198.1; NM_001113726.1.
DR PDB; 5FLM; EM; 3.40 A; J=1-67.
DR PDB; 5OIK; EM; 3.70 A; J=1-67.
DR PDBsum; 5FLM; -.
DR PDBsum; 5OIK; -.
DR AlphaFoldDB; Q32P78; -.
DR SMR; Q32P78; -.
DR DIP; DIP-61195N; -.
DR IntAct; Q32P78; 2.
DR STRING; 9913.ENSBTAP00000041501; -.
DR PaxDb; Q32P78; -.
DR PRIDE; Q32P78; -.
DR Ensembl; ENSBTAT00000043971; ENSBTAP00000041501; ENSBTAG00000031061.
DR GeneID; 617375; -.
DR KEGG; bta:617375; -.
DR CTD; 5441; -.
DR VEuPathDB; HostDB:ENSBTAG00000031061; -.
DR VGNC; VGNC:33144; POLR2L.
DR eggNOG; KOG3497; Eukaryota.
DR GeneTree; ENSGT00390000007087; -.
DR HOGENOM; CLU_143122_1_1_1; -.
DR InParanoid; Q32P78; -.
DR OMA; YCCRRMF; -.
DR OrthoDB; 1639063at2759; -.
DR TreeFam; TF103046; -.
DR Reactome; R-BTA-113418; Formation of the Early Elongation Complex.
DR Reactome; R-BTA-5250924; B-WICH complex positively regulates rRNA expression.
DR Reactome; R-BTA-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-BTA-73762; RNA Polymerase I Transcription Initiation.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000031061; Expressed in laryngeal cartilage and 110 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR GO; GO:0005665; C:RNA polymerase II, core complex; ISS:UniProtKB.
DR GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0006360; P:transcription by RNA polymerase I; IBA:GO_Central.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0042797; P:tRNA transcription by RNA polymerase III; IBA:GO_Central.
DR HAMAP; MF_00250; RNApol_arch_Rpo10; 1.
DR InterPro; IPR023580; RNA_pol_su_RPB10.
DR InterPro; IPR020789; RNA_pol_suN_Zn-BS.
DR InterPro; IPR000268; RPABC5/Rpb10.
DR PANTHER; PTHR23431; PTHR23431; 1.
DR Pfam; PF01194; RNA_pol_N; 1.
DR PIRSF; PIRSF005653; RNA_pol_N/8_sub; 1.
DR SUPFAM; SSF46924; SSF46924; 1.
DR PROSITE; PS01112; RNA_POL_N_8KD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-directed RNA polymerase; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Zinc.
FT CHAIN 1..67
FT /note="DNA-directed RNA polymerases I, II, and III subunit
FT RPABC5"
FT /id="PRO_0000291377"
FT BINDING 7
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 10
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 44
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 45
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT TURN 8..10
FT /evidence="ECO:0007829|PDB:5FLM"
FT HELIX 18..27
FT /evidence="ECO:0007829|PDB:5FLM"
FT HELIX 31..37
FT /evidence="ECO:0007829|PDB:5FLM"
FT HELIX 43..50
FT /evidence="ECO:0007829|PDB:5FLM"
FT HELIX 56..59
FT /evidence="ECO:0007829|PDB:5FLM"
SQ SEQUENCE 67 AA; 7645 MW; 9E8A72F667FE7EC5 CRC64;
MIIPVRCFTC GKIVGNKWEA YLGLLQAEYT EGDALDALGL KRYCCRRMLL AHVDLIEKLL
NYAPLEK
