ID   RPAC1_BOVIN             Reviewed;         346 AA.
AC   Q32L22;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=DNA-directed RNA polymerases I and III subunit RPAC1;
DE            Short=DNA-directed RNA polymerase I subunit C;
DE            Short=RNA polymerases I and III subunit AC1;
GN   Name=POLR1C;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Common component of RNA polymerases I and III which synthesize
CC       ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs,
CC       respectively. RPAC1 is part of the Pol core element with the central
CC       large cleft and probably a clamp element that moves to open and close
CC       the cleft (By similarity). {ECO:0000250|UniProtKB:O15160,
CC       ECO:0000250|UniProtKB:P07703}.
CC   -!- SUBUNIT: Component of the RNA polymerase I (Pol I) and RNA polymerase
CC       III (Pol III) complexes consisting of at least 13 and 17 subunits,
CC       respectively. {ECO:0000250|UniProtKB:O15160}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15160}.
CC   -!- SIMILARITY: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase
CC       subunit family. {ECO:0000305}.
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DR   EMBL; BC109803; AAI09804.1; -; mRNA.
DR   RefSeq; NP_001033213.1; NM_001038124.2.
DR   AlphaFoldDB; Q32L22; -.
DR   SMR; Q32L22; -.
DR   STRING; 9913.ENSBTAP00000025246; -.
DR   PaxDb; Q32L22; -.
DR   PeptideAtlas; Q32L22; -.
DR   PRIDE; Q32L22; -.
DR   Ensembl; ENSBTAT00000025246; ENSBTAP00000025246; ENSBTAG00000018969.
DR   GeneID; 516337; -.
DR   KEGG; bta:516337; -.
DR   CTD; 9533; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018969; -.
DR   VGNC; VGNC:33133; POLR1C.
DR   eggNOG; KOG1521; Eukaryota.
DR   GeneTree; ENSGT00950000183100; -.
DR   HOGENOM; CLU_038421_0_1_1; -.
DR   InParanoid; Q32L22; -.
DR   OMA; ECLRHPE; -.
DR   OrthoDB; 834009at2759; -.
DR   TreeFam; TF103034; -.
DR   Reactome; R-BTA-5250924; B-WICH complex positively regulates rRNA expression.
DR   Reactome; R-BTA-73762; RNA Polymerase I Transcription Initiation.
DR   Proteomes; UP000009136; Chromosome 23.
DR   Bgee; ENSBTAG00000018969; Expressed in olfactory segment of nasal mucosa and 104 other tissues.
DR   GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR   GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0001054; F:RNA polymerase I activity; IEA:InterPro.
DR   GO; GO:0001056; F:RNA polymerase III activity; IEA:InterPro.
DR   CDD; cd07032; RNAP_I_II_AC40; 1.
DR   Gene3D; 2.170.120.12; -; 1.
DR   Gene3D; 3.30.1360.10; -; 1.
DR   HAMAP; MF_00320; RNApol_arch_Rpo3; 1.
DR   InterPro; IPR001514; DNA-dir_RNA_pol_30-40kDasu_CS.
DR   InterPro; IPR011262; DNA-dir_RNA_pol_insert.
DR   InterPro; IPR011263; DNA-dir_RNA_pol_RpoA/D/Rpb3.
DR   InterPro; IPR036603; RBP11-like.
DR   InterPro; IPR022842; RNAP_Rpo3/Rpb3/RPAC1.
DR   InterPro; IPR033901; RNAPI/III_AC40.
DR   InterPro; IPR036643; RNApol_insert_sf.
DR   PANTHER; PTHR11800:SF13; PTHR11800:SF13; 1.
DR   Pfam; PF01000; RNA_pol_A_bac; 1.
DR   Pfam; PF01193; RNA_pol_L; 1.
DR   SMART; SM00662; RPOLD; 1.
DR   SUPFAM; SSF55257; SSF55257; 1.
DR   SUPFAM; SSF56553; SSF56553; 1.
DR   PROSITE; PS00446; RNA_POL_D_30KD; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; DNA-directed RNA polymerase; Nucleus; Reference proteome;
KW   Transcription.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O15160"
FT   CHAIN           2..346
FT                   /note="DNA-directed RNA polymerases I and III subunit
FT                   RPAC1"
FT                   /id="PRO_0000291381"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:O15160"
SQ   SEQUENCE   346 AA;  39116 MW;  DB5EA01B8886F738 CRC64;
     MAAAQAVEEM RTRVVLGEFG VRNVHTTDFP GNYSGYDDAW DQDRFEKNFR VDVVHMDENS
     LEFDMVGIDA AIANAFRRIL LAEVPTMAVE KVLVYNNTSI VQDEILAHRL GLIPIHADPR
     LFEYRNQGDE GGTEIDTLQF RLQVRCTRNP HAAKDSSDPN ELYVNHRVYT RHMTWVPLGN
     QADLFPEGAI RPVHDDILIA QLRPGQEIDL LMHCVKGIGK DHAKFSPVAT ASYRLLPDIT
     LLEPVEGEAA EELSRCFSPG VIEVQEIQGK KVARVANPRL DTFSREVFRN EKLKKVVRLA
     RVRDHFIFSV ESTGVLPPDV LVSEAIKVLM GKCQRFLDEL DAVQMD