ID   RPAC1_DICDI             Reviewed;         345 AA.
AC   Q54SN4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=DNA-directed RNA polymerases I and III subunit rpac1;
DE            Short=RNA polymerases I and III subunit AC1;
GN   Name=polr1c; Synonyms=rpa5; ORFNames=DDB_G0282339;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Common component of RNA polymerases I and III which synthesize
CC       ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs,
CC       respectively. RPAC1 is part of the Pol core element with the central
CC       large cleft and probably a clamp element that moves to open and close
CC       the cleft (By similarity). {ECO:0000250|UniProtKB:O15160,
CC       ECO:0000250|UniProtKB:P07703}.
CC   -!- SUBUNIT: Component of the RNA polymerase I (Pol I) and RNA polymerase
CC       III (Pol III) complexes consisting of at least 13 and 17 subunits,
CC       respectively. Interacts with RPAC19/RPAC2.
CC       {ECO:0000250|UniProtKB:O15160}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15160}.
CC   -!- SIMILARITY: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase
CC       subunit family. {ECO:0000305}.
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DR   EMBL; AAFI02000047; EAL66291.1; -; Genomic_DNA.
DR   RefSeq; XP_640267.1; XM_635175.1.
DR   AlphaFoldDB; Q54SN4; -.
DR   SMR; Q54SN4; -.
DR   STRING; 44689.DDB0216288; -.
DR   PaxDb; Q54SN4; -.
DR   PRIDE; Q54SN4; -.
DR   EnsemblProtists; EAL66291; EAL66291; DDB_G0282339.
DR   GeneID; 8623528; -.
DR   KEGG; ddi:DDB_G0282339; -.
DR   dictyBase; DDB_G0282339; rpa5.
DR   eggNOG; KOG1521; Eukaryota.
DR   HOGENOM; CLU_038421_0_1_1; -.
DR   InParanoid; Q54SN4; -.
DR   OMA; ECLRHPE; -.
DR   PhylomeDB; Q54SN4; -.
DR   Reactome; R-DDI-73762; RNA Polymerase I Transcription Initiation.
DR   Reactome; R-DDI-73772; RNA Polymerase I Promoter Escape.
DR   Reactome; R-DDI-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR   Reactome; R-DDI-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR   PRO; PR:Q54SN4; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005736; C:RNA polymerase I complex; ISS:dictyBase.
DR   GO; GO:0005666; C:RNA polymerase III complex; ISS:dictyBase.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; ISS:dictyBase.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0001054; F:RNA polymerase I activity; IEA:InterPro.
DR   GO; GO:0001056; F:RNA polymerase III activity; IEA:InterPro.
DR   GO; GO:0006360; P:transcription by RNA polymerase I; ISS:dictyBase.
DR   GO; GO:0006383; P:transcription by RNA polymerase III; ISS:dictyBase.
DR   CDD; cd07032; RNAP_I_II_AC40; 1.
DR   Gene3D; 2.170.120.12; -; 1.
DR   Gene3D; 3.30.1360.10; -; 1.
DR   HAMAP; MF_00320; RNApol_arch_Rpo3; 1.
DR   InterPro; IPR001514; DNA-dir_RNA_pol_30-40kDasu_CS.
DR   InterPro; IPR011262; DNA-dir_RNA_pol_insert.
DR   InterPro; IPR011263; DNA-dir_RNA_pol_RpoA/D/Rpb3.
DR   InterPro; IPR036603; RBP11-like.
DR   InterPro; IPR022842; RNAP_Rpo3/Rpb3/RPAC1.
DR   InterPro; IPR033901; RNAPI/III_AC40.
DR   InterPro; IPR036643; RNApol_insert_sf.
DR   PANTHER; PTHR11800:SF13; PTHR11800:SF13; 1.
DR   Pfam; PF01000; RNA_pol_A_bac; 1.
DR   Pfam; PF01193; RNA_pol_L; 1.
DR   SMART; SM00662; RPOLD; 1.
DR   SUPFAM; SSF55257; SSF55257; 1.
DR   SUPFAM; SSF56553; SSF56553; 1.
DR   PROSITE; PS00446; RNA_POL_D_30KD; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..345
FT                   /note="DNA-directed RNA polymerases I and III subunit
FT                   rpac1"
FT                   /id="PRO_0000327994"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  39443 MW;  34B3977145232515 CRC64;
     MVNKSTTNGV SDPNLENKRT KVTLTNSGVE NARGTYYSGA YTSVGYDNSF NLNRFKENFK
     INILSESANE LVFEMIGIDA PIANALRRIM ISEIPTMAIE KVYIINNTSI LQDEVLAHRL
     GMIPIKVDPR KFNFKLPNKE YTAEDTLIFQ LKVKCEKDSV TGKIINETAL SKHLIWVPTQ
     DQEEMFPNEE DRPRPMEDDI PIMKLRPGQV IDIQCYCEKN IGREHIKWSP VCTASYRLQP
     VISVDKSIKG DKANQLLEKC PKKVFDIEDS GQVVAARPLD CTMCRECIRD PEFEQNVKIE
     RVRDHFIFSI ESTGALKSRE IFQEAIKIFI EKCNIVEESI NKLVN