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AB2A_ARATH
ID   AB2A_ARATH              Reviewed;         983 AA.
AC   Q84K47; Q9STU0;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=ABC transporter A family member 2;
DE            Short=ABC transporter ABCA.2;
DE            Short=AtABCA2;
DE   AltName: Full=ABC2 homolog 1;
GN   Name=ABCA2; Synonyms=ATH1; OrderedLocusNames=At3g47730; ORFNames=T23J7.60;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA   Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT   "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL   J. Biol. Chem. 276:30231-30244(2001).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA   Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA   Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA   Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT   "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL   Trends Plant Sci. 13:151-159(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC       CPR flippase (TC 3.A.1.211) subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB41856.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL049746; CAB41856.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE78323.1; -; Genomic_DNA.
DR   EMBL; BT004197; AAO42215.1; -; mRNA.
DR   EMBL; BT005456; AAO63876.1; -; mRNA.
DR   PIR; T07712; T07712.
DR   RefSeq; NP_190357.2; NM_114641.4.
DR   AlphaFoldDB; Q84K47; -.
DR   SMR; Q84K47; -.
DR   STRING; 3702.AT3G47730.1; -.
DR   iPTMnet; Q84K47; -.
DR   SwissPalm; Q84K47; -.
DR   PaxDb; Q84K47; -.
DR   PRIDE; Q84K47; -.
DR   ProteomicsDB; 245092; -.
DR   EnsemblPlants; AT3G47730.1; AT3G47730.1; AT3G47730.
DR   GeneID; 823927; -.
DR   Gramene; AT3G47730.1; AT3G47730.1; AT3G47730.
DR   KEGG; ath:AT3G47730; -.
DR   Araport; AT3G47730; -.
DR   TAIR; locus:2100367; AT3G47730.
DR   eggNOG; KOG0059; Eukaryota.
DR   HOGENOM; CLU_000604_19_5_1; -.
DR   InParanoid; Q84K47; -.
DR   OMA; RTIWSLF; -.
DR   OrthoDB; 131191at2759; -.
DR   PhylomeDB; Q84K47; -.
DR   BioCyc; ARA:AT3G47730-MON; -.
DR   PRO; PR:Q84K47; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q84K47; baseline and differential.
DR   Genevisible; Q84K47; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR   GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR026082; ABCA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR19229; PTHR19229; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..983
FT                   /note="ABC transporter A family member 2"
FT                   /id="PRO_0000240323"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          518..763
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   REGION          963..983
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         564..571
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   983 AA;  108688 MW;  2032DA9BFCA34629 CRC64;
     MTLQRGLPLL LQQYTALFKK NLLLSWRSKR ATFLQLFASF FFILLIFCIQ AAMEKSFASS
     TALKTVTDPT ALISPPIPPC EDKFFVNLPC YDFVWSGNRS SKVTQIVNAI MKNNPGRSIP
     IEKVRSFVDP EAVDTWLMAN PLLVPGALHF IERNATVISY GIQTNSTPEM NRGRFEDPTF
     KFQIPLQIAA EREIARSLIG DPNFNWVVGF KEFPHPTIEA IVALDTIGPT FFLAVAMFGF
     VLQISSLITE KELKLRQAMT MMGVFDTAYW LSWLTWEGIL TAISALLTVL FGMMFQFDFF
     LKNSFPVVFL LFMLFQFNLI GLAFMLSAFI SKSTSATTVG FFVFLVGFVT QLATSSGFPY
     AKKYSRMIRA LWSLFPPNTF SQGLKLLADA TSTPQDPGIS WSKRAECGPN DDTGCVLTIN
     DIYLWLLGTF FLWFVLALYF DNITPNASGV RKSIFYFLKP GYWTGKGGNR VEEGGICSCI
     GSVPPVDHIT PDDEDVLEEE TLVKQHSMEG LVDPNVAVQI RGLAKTYPGT TKFGCCKCKK
     TSPFHALKGL WMNIAKDQLF CLLGPNGAGK TTTINCLTGL FPVTGGDALI YGNSIRSSVG
     MSNIRKMIGV CPQFDILWDA LSGEEHLKLF ASIKGLPPSS INSMVEKSLA EVKLTEAGKI
     RAGSYSGGMK RRLSVAVSLI GDPKLVFLDE PTTGMDPITR RHVWDIIQET KKGRAIILTT
     HSMEEADILS DRIGIMAKGR LRCIGTSIRL KSRFGTGFIA NISFVESNNH NGEAGSDSRE
     PVKKFFKDHL KVKPIEENKA FMTFVIPHDK ENLLTSFFAE LQDREEEFGI SDIQLGLATL
     EEVFLNIARK AELESAAVDG TMVTLDLTSG SSVEIPVGAR FIGIPGTETA ENPRGVMVEV
     YWQQDESGSL CISGHSTEMP IPENIPVTDP VAPGHGGVNL LGRRGRRQVQ GIVIDPEFAT
     FTRSGSTSSR RFSRSGSSRR FSS
 
 
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