AB2A_ARATH
ID AB2A_ARATH Reviewed; 983 AA.
AC Q84K47; Q9STU0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=ABC transporter A family member 2;
DE Short=ABC transporter ABCA.2;
DE Short=AtABCA2;
DE AltName: Full=ABC2 homolog 1;
GN Name=ABCA2; Synonyms=ATH1; OrderedLocusNames=At3g47730; ORFNames=T23J7.60;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC CPR flippase (TC 3.A.1.211) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB41856.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049746; CAB41856.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE78323.1; -; Genomic_DNA.
DR EMBL; BT004197; AAO42215.1; -; mRNA.
DR EMBL; BT005456; AAO63876.1; -; mRNA.
DR PIR; T07712; T07712.
DR RefSeq; NP_190357.2; NM_114641.4.
DR AlphaFoldDB; Q84K47; -.
DR SMR; Q84K47; -.
DR STRING; 3702.AT3G47730.1; -.
DR iPTMnet; Q84K47; -.
DR SwissPalm; Q84K47; -.
DR PaxDb; Q84K47; -.
DR PRIDE; Q84K47; -.
DR ProteomicsDB; 245092; -.
DR EnsemblPlants; AT3G47730.1; AT3G47730.1; AT3G47730.
DR GeneID; 823927; -.
DR Gramene; AT3G47730.1; AT3G47730.1; AT3G47730.
DR KEGG; ath:AT3G47730; -.
DR Araport; AT3G47730; -.
DR TAIR; locus:2100367; AT3G47730.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_5_1; -.
DR InParanoid; Q84K47; -.
DR OMA; RTIWSLF; -.
DR OrthoDB; 131191at2759; -.
DR PhylomeDB; Q84K47; -.
DR BioCyc; ARA:AT3G47730-MON; -.
DR PRO; PR:Q84K47; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q84K47; baseline and differential.
DR Genevisible; Q84K47; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..983
FT /note="ABC transporter A family member 2"
FT /id="PRO_0000240323"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 518..763
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 963..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 564..571
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 983 AA; 108688 MW; 2032DA9BFCA34629 CRC64;
MTLQRGLPLL LQQYTALFKK NLLLSWRSKR ATFLQLFASF FFILLIFCIQ AAMEKSFASS
TALKTVTDPT ALISPPIPPC EDKFFVNLPC YDFVWSGNRS SKVTQIVNAI MKNNPGRSIP
IEKVRSFVDP EAVDTWLMAN PLLVPGALHF IERNATVISY GIQTNSTPEM NRGRFEDPTF
KFQIPLQIAA EREIARSLIG DPNFNWVVGF KEFPHPTIEA IVALDTIGPT FFLAVAMFGF
VLQISSLITE KELKLRQAMT MMGVFDTAYW LSWLTWEGIL TAISALLTVL FGMMFQFDFF
LKNSFPVVFL LFMLFQFNLI GLAFMLSAFI SKSTSATTVG FFVFLVGFVT QLATSSGFPY
AKKYSRMIRA LWSLFPPNTF SQGLKLLADA TSTPQDPGIS WSKRAECGPN DDTGCVLTIN
DIYLWLLGTF FLWFVLALYF DNITPNASGV RKSIFYFLKP GYWTGKGGNR VEEGGICSCI
GSVPPVDHIT PDDEDVLEEE TLVKQHSMEG LVDPNVAVQI RGLAKTYPGT TKFGCCKCKK
TSPFHALKGL WMNIAKDQLF CLLGPNGAGK TTTINCLTGL FPVTGGDALI YGNSIRSSVG
MSNIRKMIGV CPQFDILWDA LSGEEHLKLF ASIKGLPPSS INSMVEKSLA EVKLTEAGKI
RAGSYSGGMK RRLSVAVSLI GDPKLVFLDE PTTGMDPITR RHVWDIIQET KKGRAIILTT
HSMEEADILS DRIGIMAKGR LRCIGTSIRL KSRFGTGFIA NISFVESNNH NGEAGSDSRE
PVKKFFKDHL KVKPIEENKA FMTFVIPHDK ENLLTSFFAE LQDREEEFGI SDIQLGLATL
EEVFLNIARK AELESAAVDG TMVTLDLTSG SSVEIPVGAR FIGIPGTETA ENPRGVMVEV
YWQQDESGSL CISGHSTEMP IPENIPVTDP VAPGHGGVNL LGRRGRRQVQ GIVIDPEFAT
FTRSGSTSSR RFSRSGSSRR FSS