RPAC2_CAEEL
ID RPAC2_CAEEL Reviewed; 144 AA.
AC P34476;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Probable DNA-directed RNA polymerases I and III subunit RPAC2;
DE Short=RNA polymerases I and III subunit AC2;
DE AltName: Full=AC19;
DE AltName: Full=DNA-directed RNA polymerase I subunit D;
GN Name=rpac-19; ORFNames=F58A4.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Common core component of RNA polymerases I and III which synthesize
CC ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs,
CC respectively (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase I (Pol I) and RNA polymerase
CC III (Pol III) complexes consisting of at least 13 and 17 subunits,
CC respectively. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA
CC polymerase subunit family. {ECO:0000305}.
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DR EMBL; Z22179; CAA80165.1; -; Genomic_DNA.
DR PIR; S40981; S40981.
DR RefSeq; NP_499132.1; NM_066731.5.
DR AlphaFoldDB; P34476; -.
DR SMR; P34476; -.
DR BioGRID; 41557; 15.
DR STRING; 6239.F58A4.9.1; -.
DR EPD; P34476; -.
DR PaxDb; P34476; -.
DR PeptideAtlas; P34476; -.
DR EnsemblMetazoa; F58A4.9.1; F58A4.9.1; WBGene00010230.
DR GeneID; 176362; -.
DR KEGG; cel:CELE_F58A4.9; -.
DR UCSC; F58A4.9.2; c. elegans.
DR CTD; 176362; -.
DR WormBase; F58A4.9; CE00225; WBGene00010230; rpac-19.
DR eggNOG; KOG3438; Eukaryota.
DR GeneTree; ENSGT00550000075160; -.
DR HOGENOM; CLU_090381_3_0_1; -.
DR InParanoid; P34476; -.
DR OMA; MRIQMYD; -.
DR OrthoDB; 1398114at2759; -.
DR PhylomeDB; P34476; -.
DR PRO; PR:P34476; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00010230; Expressed in adult organism and 4 other tissues.
DR GO; GO:0005736; C:RNA polymerase I complex; IBA:GO_Central.
DR GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07029; RNAP_I_III_AC19; 1.
DR Gene3D; 3.30.1360.10; -; 1.
DR HAMAP; MF_00261; RNApol_arch_Rpo11; 1.
DR InterPro; IPR036603; RBP11-like.
DR InterPro; IPR009025; RBP11-like_dimer.
DR InterPro; IPR008193; RNA_pol_Rpb11_13-16kDa_CS.
DR InterPro; IPR033898; RNAP_AC19.
DR Pfam; PF13656; RNA_pol_L_2; 1.
DR SUPFAM; SSF55257; SSF55257; 1.
DR PROSITE; PS01154; RNA_POL_L_13KD; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..144
FT /note="Probable DNA-directed RNA polymerases I and III
FT subunit RPAC2"
FT /id="PRO_0000149320"
FT REGION 14..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 144 AA; 16595 MW; 6611584EF4EDE756 CRC64;
MGKKNEKIVE EAEKVEAETM EVDEQPQETP QVDDEEDLNV PSKKKMEILD PKSFEQDPSN
LTLIMYEEDH TIGNSIKHIL SRMDEVEFCG YNVPHPLEDK ILFRVQTKDG INALEVLAKA
FESVEQIFST IRGKFEESYE QSQS
