RPAC2_MOUSE
ID RPAC2_MOUSE Reviewed; 133 AA.
AC P97304;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=DNA-directed RNA polymerases I and III subunit RPAC2;
DE Short=RNA polymerases I and III subunit AC2;
DE AltName: Full=AC19;
DE AltName: Full=DNA-directed RNA polymerase I subunit D;
DE AltName: Full=RNA polymerase I 16 kDa subunit;
DE Short=RPA16;
GN Name=Polr1d; Synonyms=Rpo1-3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8955128; DOI=10.1074/jbc.271.51.32881;
RA Yao Y., Yamamoto K., Nishi Y., Nogi Y., Muramatsu M.;
RT "Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa
RT subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III.";
RL J. Biol. Chem. 271:32881-32885(1996).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Common core component of RNA polymerases I and III which synthesize
CC ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs,
CC respectively.
CC -!- SUBUNIT: Component of the RNA polymerase I (Pol I) and RNA polymerase
CC III (Pol III) complexes consisting of at least 13 and 17 subunits,
CC respectively. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA
CC polymerase subunit family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D86609; BAA13139.1; -; mRNA.
DR CCDS; CCDS19876.1; -.
DR RefSeq; NP_033113.1; NM_009087.2.
DR AlphaFoldDB; P97304; -.
DR SMR; P97304; -.
DR BioGRID; 202994; 1.
DR IntAct; P97304; 1.
DR MINT; P97304; -.
DR STRING; 10090.ENSMUSP00000058355; -.
DR iPTMnet; P97304; -.
DR PhosphoSitePlus; P97304; -.
DR EPD; P97304; -.
DR PaxDb; P97304; -.
DR PeptideAtlas; P97304; -.
DR PRIDE; P97304; -.
DR ProteomicsDB; 262701; -.
DR Antibodypedia; 22678; 113 antibodies from 25 providers.
DR DNASU; 20018; -.
DR Ensembl; ENSMUST00000050970; ENSMUSP00000058355; ENSMUSG00000029642.
DR GeneID; 20018; -.
DR KEGG; mmu:20018; -.
DR UCSC; uc009anu.2; mouse.
DR CTD; 51082; -.
DR MGI; MGI:108403; Polr1d.
DR VEuPathDB; HostDB:ENSMUSG00000029642; -.
DR eggNOG; KOG3438; Eukaryota.
DR GeneTree; ENSGT00550000075160; -.
DR HOGENOM; CLU_090381_4_1_1; -.
DR InParanoid; P97304; -.
DR OMA; MRIQMYD; -.
DR OrthoDB; 1398114at2759; -.
DR PhylomeDB; P97304; -.
DR TreeFam; TF103035; -.
DR BioGRID-ORCS; 20018; 26 hits in 71 CRISPR screens.
DR ChiTaRS; Polr1d; mouse.
DR PRO; PR:P97304; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P97304; protein.
DR Bgee; ENSMUSG00000029642; Expressed in floor plate of midbrain and 259 other tissues.
DR ExpressionAtlas; P97304; baseline and differential.
DR Genevisible; P97304; MM.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005736; C:RNA polymerase I complex; IDA:MGI.
DR GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07029; RNAP_I_III_AC19; 1.
DR Gene3D; 3.30.1360.10; -; 1.
DR HAMAP; MF_00261; RNApol_arch_Rpo11; 1.
DR InterPro; IPR036603; RBP11-like.
DR InterPro; IPR009025; RBP11-like_dimer.
DR InterPro; IPR008193; RNA_pol_Rpb11_13-16kDa_CS.
DR InterPro; IPR033898; RNAP_AC19.
DR Pfam; PF13656; RNA_pol_L_2; 1.
DR SUPFAM; SSF55257; SSF55257; 1.
DR PROSITE; PS01154; RNA_POL_L_13KD; 1.
PE 1: Evidence at protein level;
KW Acetylation; DNA-directed RNA polymerase; Nucleus; Reference proteome;
KW Transcription.
FT CHAIN 1..133
FT /note="DNA-directed RNA polymerases I and III subunit
FT RPAC2"
FT /id="PRO_0000149317"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P0DPB6"
SQ SEQUENCE 133 AA; 15072 MW; D355055B67C7388B CRC64;
MEDDQELERK ISGLKTSMAE GERKTALEMV QAAGTDRQCV TFVLHEEDHT LGNCLRYIIM
KNPEVEFCGY TTTHPSESKI NLRIQTRGAL PAVEPFQKGL NELLNVCQHV LVKFEASIKD
YKAKKASKKE PTF
