ID   RPAP3_XENLA             Reviewed;         660 AA.
AC   Q6NU95;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=RNA polymerase II-associated protein 3;
GN   Name=rpap3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May for an interface between the RNA polymerase II enzyme and
CC       chaperone/scaffolding protein. {ECO:0000250|UniProtKB:Q9H6T3}.
CC   -!- SIMILARITY: Belongs to the RPAP3 family. {ECO:0000305}.
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DR   EMBL; BC068702; AAH68702.1; -; mRNA.
DR   RefSeq; NP_001084525.1; NM_001091056.1.
DR   AlphaFoldDB; Q6NU95; -.
DR   SMR; Q6NU95; -.
DR   BioGRID; 100894; 2.
DR   IntAct; Q6NU95; 1.
DR   MaxQB; Q6NU95; -.
DR   DNASU; 414472; -.
DR   GeneID; 414472; -.
DR   KEGG; xla:414472; -.
DR   CTD; 414472; -.
DR   Xenbase; XB-GENE-5779079; rpap3.L.
DR   OrthoDB; 1617844at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 414472; Expressed in gastrula and 19 other tissues.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR025986; RPAP3-like_C.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF13877; RPAP3_C; 1.
DR   Pfam; PF13176; TPR_7; 1.
DR   Pfam; PF13181; TPR_8; 3.
DR   SMART; SM00028; TPR; 6.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS50005; TPR; 5.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..660
FT                   /note="RNA polymerase II-associated protein 3"
FT                   /id="PRO_0000302798"
FT   REPEAT          8..41
FT                   /note="TPR 1"
FT   REPEAT          132..165
FT                   /note="TPR 2"
FT   REPEAT          167..199
FT                   /note="TPR 3"
FT   REPEAT          200..233
FT                   /note="TPR 4"
FT   REPEAT          284..317
FT                   /note="TPR 5"
FT   REPEAT          319..351
FT                   /note="TPR 6"
FT   REPEAT          352..385
FT                   /note="TPR 7"
FT   REPEAT          502..539
FT                   /note="TPR 8"
FT   REGION          35..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          496..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  75106 MW;  D856088524557499 CRC64;
     MSSPSKAIEL QLQMKQNAED LQDFMREMES WEKDIKQKDA KLRNQTGVEN QILPPIRNKD
     FKKKKKNKPK PPLEKSQEDC LNPKKKLLDY EYWDKLDVDK ALEDIDKDNS NETSSDSECG
     DEDAITVDTE KALSEKEKGN NYFKSGKYDE AIECYTRGMD ADPYNAILPT NRASAFFRLK
     KFAVAESDCN LAIALNRDYA KAYARRGAAR LALKNLQGAK EDYEKVLELD ANNFEAKNEL
     RKINQELYSS ASDVQENMAT EAKITVENEE EKKQIEIQQR KQQAIMQKDL GNAYFKEGKY
     EIAIECYSQG MEADNTNALL PANRAMAYLK IQKYKEAEAD CTLAISLDAS YCKAFARRGT
     ASIMLGKQKE AKEDFEMVLK LDPGNKQAVL ELAKISQELR SIEKDRNGNK DSNQRKLINT
     VEKLPHLRST KPLRRMVIEE VGGPAEIFNT SLKETNHRKA DSVDLTAETN TQDLNQEQNI
     CNSPDVPSPK IPKIEEISDT PGSCEPTTGE DYLTSRPSPP KIEKVVSTFS ESLNIGIPAV
     PTNSFQLESD FRRLKGNPDL LYVYLKQIEP TLYGKLFKKA LDPDLFSDIL TILREQFINK
     DSPDLIFEIL QRLSELKRFD MAVMFLSESD KNNAHILFSH LEQSMNANVS FNALKKKYGL