ID   RPAP3_XENTR             Reviewed;         657 AA.
AC   Q28IV3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=RNA polymerase II-associated protein 3;
GN   Name=rpap3; ORFNames=TNeu057e12.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Skin;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May for an interface between the RNA polymerase II enzyme and
CC       chaperone/scaffolding protein. {ECO:0000250|UniProtKB:Q9H6T3}.
CC   -!- SIMILARITY: Belongs to the RPAP3 family. {ECO:0000305}.
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DR   EMBL; CR760208; CAJ83035.1; -; mRNA.
DR   EMBL; BC121516; AAI21517.1; -; mRNA.
DR   RefSeq; NP_001016680.1; NM_001016680.2.
DR   RefSeq; XP_012814491.1; XM_012959037.2.
DR   AlphaFoldDB; Q28IV3; -.
DR   SMR; Q28IV3; -.
DR   STRING; 8364.ENSXETP00000028675; -.
DR   PaxDb; Q28IV3; -.
DR   GeneID; 549434; -.
DR   KEGG; xtr:549434; -.
DR   CTD; 79657; -.
DR   Xenbase; XB-GENE-5779008; rpap3.
DR   eggNOG; KOG4648; Eukaryota.
DR   HOGENOM; CLU_023272_1_0_1; -.
DR   InParanoid; Q28IV3; -.
DR   OrthoDB; 1617844at2759; -.
DR   PhylomeDB; Q28IV3; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014674; Expressed in testis and 14 other tissues.
DR   GO; GO:0101031; C:chaperone complex; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR025986; RPAP3-like_C.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF13877; RPAP3_C; 1.
DR   Pfam; PF13176; TPR_7; 1.
DR   Pfam; PF13181; TPR_8; 3.
DR   SMART; SM00028; TPR; 6.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS50005; TPR; 5.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..657
FT                   /note="RNA polymerase II-associated protein 3"
FT                   /id="PRO_0000302799"
FT   REPEAT          132..165
FT                   /note="TPR 2"
FT   REPEAT          167..199
FT                   /note="TPR 3"
FT   REPEAT          200..233
FT                   /note="TPR 4"
FT   REPEAT          284..317
FT                   /note="TPR 5"
FT   REPEAT          319..351
FT                   /note="TPR 6"
FT   REPEAT          352..385
FT                   /note="TPR 7"
FT   REPEAT          503..536
FT                   /note="TPR 8"
FT   REGION          39..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          496..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        498..517
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   657 AA;  74890 MW;  593E84455BB07987 CRC64;
     MSSPSKAIEL QLQMKQNAEE LQDFMRDLEN WEKDIKQTDA KLRNQTGVDS QILPPIRNKD
     FKKKKKSKSK PPLEKKSQED EIKPKKKLLD YEYWDKLDVD RALEDIDKDN NESSSESECG
     DEDGITVDTE KALLEKEKGN NYFKSGQYDE AIECYTRGMD ADPYNAVLPT NRASAFFRLK
     KYAVAESDCN LAIALNHNYA KAYARRGAAR LALKDLQGAK EDYEKVLELD VNNFEAKNEL
     RKINKELQSS TSDVQEKEAI EEKITVENEE EKKQIEIQQR KQQAIMQKDL GNAYFKEGKY
     EIAIDCYSQG MEADTTNALL PANRAMAYLK IQKYKEAETD CTLAISLDAS YCKAFARRGT
     ARIMLGKQKE AKEDFEMVLK LDPGNKQAVL ELEKISRELR SNEKDTKGNK ERKLINAVEK
     LPHQRSTKPL RRMVIEEVGG PVESCISSLN ESNHGKADSM DLITKADKQD LNEEQNFCSL
     PDVPSAKVPK IEEISDTYGS CEPSSGEEHS VSQPSPPKIE KVVTTFSESL NIGIPVVPTN
     SFQLESDFRR LKGNPDLLYR YLKQIEPSFY GKLFQKALDP DLFSEILTIL REQYINKDSC
     DLIFEILQRL SELKRFDMAV MFLSGSDRNN AHILFSHLEQ SLKGSVSLNA LKKKYGL