ID   RPAR_RHOPA              Reviewed;         243 AA.
AC   Q6NCZ5;
DT   29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=HTH-type quorum sensing-dependent transcriptional regulator RpaR {ECO:0000305};
DE   AltName: Full=4-coumaroyl-homoserine lactone receptor {ECO:0000305};
DE            Short=pC-HSL receptor {ECO:0000303|PubMed:18563084};
GN   Name=rpaR {ECO:0000303|PubMed:18563084};
GN   OrderedLocusNames=RPA0321 {ECO:0000312|EMBL:CAE25765.1};
OS   Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=258594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-98 / CGA009;
RX   PubMed=14704707; DOI=10.1038/nbt923;
RA   Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L.,
RA   Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R.,
RA   Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C.,
RA   Harrison F.H., Gibson J., Harwood C.S.;
RT   "Complete genome sequence of the metabolically versatile photosynthetic
RT   bacterium Rhodopseudomonas palustris.";
RL   Nat. Biotechnol. 22:55-61(2004).
RN   [2]
RP   FUNCTION IN QUORUM-SENSING.
RC   STRAIN=ATCC BAA-98 / CGA009;
RX   PubMed=18563084; DOI=10.1038/nature07088;
RA   Schaefer A.L., Greenberg E.P., Oliver C.M., Oda Y., Huang J.J.,
RA   Bittan-Banin G., Peres C.M., Schmidt S., Juhaszova K., Sufrin J.R.,
RA   Harwood C.S.;
RT   "A new class of homoserine lactone quorum-sensing signals.";
RL   Nature 454:595-599(2008).
CC   -!- FUNCTION: Responds to the quorum-sensing autoinducer 4-coumaroyl-
CC       homoserine lactone to regulate expression of several genes. Represses
CC       expression of rpaI in the absence of the inducer.
CC       {ECO:0000269|PubMed:18563084}.
CC   -!- SIMILARITY: Belongs to the autoinducer-regulated transcriptional
CC       regulatory protein family. {ECO:0000305}.
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DR   EMBL; BX572594; CAE25765.1; -; Genomic_DNA.
DR   RefSeq; WP_011155889.1; NC_005296.1.
DR   AlphaFoldDB; Q6NCZ5; -.
DR   SMR; Q6NCZ5; -.
DR   STRING; 258594.RPA0321; -.
DR   PRIDE; Q6NCZ5; -.
DR   DNASU; 2689487; -.
DR   EnsemblBacteria; CAE25765; CAE25765; RPA0321.
DR   GeneID; 66891331; -.
DR   KEGG; rpa:RPA0321; -.
DR   eggNOG; COG2197; Bacteria.
DR   HOGENOM; CLU_072786_4_1_5; -.
DR   OMA; NFHIRSV; -.
DR   PhylomeDB; Q6NCZ5; -.
DR   BioCyc; RPAL258594:TX73_RS01660-MON; -.
DR   Proteomes; UP000001426; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.80; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR   InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03472; Autoind_bind; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF75516; SSF75516; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Quorum sensing; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..243
FT                   /note="HTH-type quorum sensing-dependent transcriptional
FT                   regulator RpaR"
FT                   /id="PRO_0000430602"
FT   DOMAIN          174..239
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        198..217
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   243 AA;  26938 MW;  2C3950162EC4D16C CRC64;
     MIVGEDQLWG RRALEFVDSV ERLEAPALIS RFESLIASCG FTAYIMAGLP SRNAGLPELT
     LANGWPRDWF DLYVSENFSA VDPVPRHGAT TVHPFVWSDA PYDRDRDPAA HRVMTRAAEF
     GLVEGYCIPL HYDDGSAAIS MAGKDPDLSP AARGAMQLVS IYAHSRLRAL SRPKPIRRNR
     LTPRECEILQ WAAQGKTAWE ISVILCITER TVKFHLIEAA RKLDAANRTA AVAKALTLGL
     IRL