RPB11_CAEEL
ID RPB11_CAEEL Reviewed; 122 AA.
AC Q9XVH6;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Probable DNA-directed RNA polymerase II subunit RPB11;
DE Short=RNA polymerase II subunit B11;
DE AltName: Full=DNA-directed RNA polymerase II subunit J;
GN Name=rpb-11; ORFNames=W01G7.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Component of RNA polymerase II which synthesizes mRNA precursors and
CC many functional non-coding RNAs. Pol II is the central component of the
CC basal RNA polymerase II transcription machinery. It is composed of
CC mobile elements that move relative to each other. RPB11 is part of the
CC core element with the central large cleft (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase II (Pol II) complex consisting
CC of 12 subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA
CC polymerase subunit family. {ECO:0000305}.
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DR EMBL; Z81135; CAB03455.1; -; Genomic_DNA.
DR PIR; T26065; T26065.
DR RefSeq; NP_496942.1; NM_064541.3.
DR AlphaFoldDB; Q9XVH6; -.
DR SMR; Q9XVH6; -.
DR BioGRID; 40340; 30.
DR IntAct; Q9XVH6; 3.
DR STRING; 6239.W01G7.3.2; -.
DR EPD; Q9XVH6; -.
DR PaxDb; Q9XVH6; -.
DR PeptideAtlas; Q9XVH6; -.
DR EnsemblMetazoa; W01G7.3.1; W01G7.3.1; WBGene00012187.
DR GeneID; 175056; -.
DR KEGG; cel:CELE_W01G7.3; -.
DR CTD; 175056; -.
DR WormBase; W01G7.3; CE18986; WBGene00012187; rpb-11.
DR eggNOG; KOG4392; Eukaryota.
DR GeneTree; ENSGT00550000074975; -.
DR HOGENOM; CLU_090381_2_2_1; -.
DR InParanoid; Q9XVH6; -.
DR OMA; LEQACTK; -.
DR OrthoDB; 1398114at2759; -.
DR PhylomeDB; Q9XVH6; -.
DR Reactome; R-CEL-112382; Formation of RNA Pol II elongation complex.
DR Reactome; R-CEL-113418; Formation of the Early Elongation Complex.
DR Reactome; R-CEL-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-CEL-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-CEL-6781823; Formation of TC-NER Pre-Incision Complex.
DR Reactome; R-CEL-6782135; Dual incision in TC-NER.
DR Reactome; R-CEL-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR Reactome; R-CEL-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR Reactome; R-CEL-6803529; FGFR2 alternative splicing.
DR Reactome; R-CEL-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-CEL-72086; mRNA Capping.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72165; mRNA Splicing - Minor Pathway.
DR Reactome; R-CEL-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-CEL-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-CEL-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-CEL-75955; RNA Polymerase II Transcription Elongation.
DR Reactome; R-CEL-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Reactome; R-CEL-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR Reactome; R-CEL-9018519; Estrogen-dependent gene expression.
DR PRO; PR:Q9XVH6; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00012187; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005665; C:RNA polymerase II, core complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0001055; F:RNA polymerase II activity; IEA:InterPro.
DR CDD; cd06926; RNAP_II_RPB11; 1.
DR Gene3D; 3.30.1360.10; -; 1.
DR HAMAP; MF_00261; RNApol_arch_Rpo11; 1.
DR InterPro; IPR037685; RBP11.
DR InterPro; IPR036603; RBP11-like.
DR InterPro; IPR009025; RBP11-like_dimer.
DR InterPro; IPR008193; RNA_pol_Rpb11_13-16kDa_CS.
DR Pfam; PF13656; RNA_pol_L_2; 1.
DR SUPFAM; SSF55257; SSF55257; 1.
DR PROSITE; PS01154; RNA_POL_L_13KD; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..122
FT /note="Probable DNA-directed RNA polymerase II subunit
FT RPB11"
FT /id="PRO_0000149311"
SQ SEQUENCE 122 AA; 13697 MW; 3D1B051983FEBFD8 CRC64;
MNAPAAFESF LLLDDKKFYI EKDTKVPNAA IFTIMKEDHT LGNMLKIQLL KDPEVLFAGY
KNPHPLEHKI LLRIQTTNNT TPADALTTAI TDLVGELSLL EHRIDAAIKK CTQSGDQERG
YN
