RPB11_PLAF7
ID RPB11_PLAF7 Reviewed; 126 AA.
AC Q8IER7;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Probable DNA-directed RNA polymerase II subunit RPB11;
DE Short=RNA polymerase II subunit B11;
DE AltName: Full=DNA-directed RNA polymerase II subunit J;
GN ORFNames=PF13_0023;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Component of RNA polymerase II which synthesizes mRNA precursors and
CC many functional non-coding RNAs. Pol II is the central component of the
CC basal RNA polymerase II transcription machinery. It is composed of
CC mobile elements that move relative to each other. RPB11 is part of the
CC core element with the central large cleft (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase II (Pol II) complex consisting
CC of 12 subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA
CC polymerase subunit family. {ECO:0000305}.
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DR EMBL; AL844509; CAD52182.1; -; Genomic_DNA.
DR RefSeq; XP_001349775.1; XM_001349739.1.
DR AlphaFoldDB; Q8IER7; -.
DR SMR; Q8IER7; -.
DR STRING; 5833.PF13_0023; -.
DR PRIDE; Q8IER7; -.
DR EnsemblProtists; CAD52182; CAD52182; PF3D7_1304900.
DR GeneID; 814002; -.
DR KEGG; pfa:PF3D7_1304900; -.
DR VEuPathDB; PlasmoDB:PF3D7_1304900; -.
DR HOGENOM; CLU_090381_2_1_1; -.
DR InParanoid; Q8IER7; -.
DR OMA; CNIFTIK; -.
DR PhylomeDB; Q8IER7; -.
DR Reactome; R-PFA-113418; Formation of the Early Elongation Complex.
DR Reactome; R-PFA-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-PFA-6781823; Formation of TC-NER Pre-Incision Complex.
DR Reactome; R-PFA-72086; mRNA Capping.
DR Reactome; R-PFA-72203; Processing of Capped Intron-Containing Pre-mRNA.
DR Reactome; R-PFA-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-PFA-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR Proteomes; UP000001450; Chromosome 13.
DR GO; GO:0005665; C:RNA polymerase II, core complex; IBA:GO_Central.
DR GO; GO:0016591; C:RNA polymerase II, holoenzyme; ISS:GeneDB.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; ISS:GeneDB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0001055; F:RNA polymerase II activity; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:GeneDB.
DR CDD; cd06926; RNAP_II_RPB11; 1.
DR Gene3D; 3.30.1360.10; -; 1.
DR HAMAP; MF_00261; RNApol_arch_Rpo11; 1.
DR InterPro; IPR037685; RBP11.
DR InterPro; IPR036603; RBP11-like.
DR InterPro; IPR009025; RBP11-like_dimer.
DR InterPro; IPR008193; RNA_pol_Rpb11_13-16kDa_CS.
DR Pfam; PF13656; RNA_pol_L_2; 1.
DR SUPFAM; SSF55257; SSF55257; 1.
DR PROSITE; PS01154; RNA_POL_L_13KD; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..126
FT /note="Probable DNA-directed RNA polymerase II subunit
FT RPB11"
FT /id="PRO_0000232464"
SQ SEQUENCE 126 AA; 14125 MW; 1D59E7CBC7E7CFB4 CRC64;
MSVPTLSNKP ETVDLLVLAP GEKKVTCTIS DKGDCNIFVI KLEDHTIGNL IKIQLCQDPK
VLFAAYRQPH PLQNAIEITI KPKGYAGVKL LSDNVNNILS QVATLKENFA KKIQKYKESN
SYYEDY
