ID   RPB6_ASFB7              Reviewed;         147 AA.
AC   P42484;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA-directed RNA polymerase RPB6 homolog {ECO:0000303|PubMed:23041356};
DE            Short=RPB6 homolog {ECO:0000305};
GN   OrderedLocusNames=Ba71V-069; ORFNames=C147L;
OS   African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10498;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11831707; DOI=10.1006/viro.1995.1149;
RA   Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C.,
RA   Rodriguez J.F., Vinuela E.;
RT   "Analysis of the complete nucleotide sequence of African swine fever
RT   virus.";
RL   Virology 208:249-278(1995).
RN   [2]
RP   FUNCTION.
RX   PubMed=8332503; DOI=10.1093/nar/21.12.2940;
RA   Lu Z., Kutish G.F., Sussman M.D., Rock D.L.;
RT   "An African swine fever virus gene with a similarity to eukaryotic RNA
RT   polymerase subunit 6.";
RL   Nucleic Acids Res. 21:2940-2940(1993).
RN   [3]
RP   REVIEW.
RX   PubMed=23041356; DOI=10.1016/j.virusres.2012.09.014;
RA   Rodriguez J.M., Salas M.L.;
RT   "African swine fever virus transcription.";
RL   Virus Res. 173:15-28(2013).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=30185597; DOI=10.1128/jvi.01293-18;
RA   Alejo A., Matamoros T., Guerra M., Andres G.;
RT   "A Proteomic Atlas of the African Swine Fever Virus Particle.";
RL   J. Virol. 92:0-0(2018).
RN   [5]
RP   REVIEW.
RX   PubMed=32725217; DOI=10.1042/bst20191108;
RA   Cackett G., Sykora M., Werner F.;
RT   "Transcriptome view of a killer: African swine fever virus.";
RL   Biochem. Soc. Trans. 48:1569-1581(2020).
CC   -!- FUNCTION: Component of the DNA-directed RNA polymerase (RNAP) that
CC       catalyzes the transcription in the cytoplasm of viral DNA into RNA
CC       using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000305|PubMed:8332503}.
CC   -!- SUBUNIT: Part of the viral DNA-directed RNA polymerase that consists of
CC       8 polII-like subunits (RPB1, RPB2, RPB3, RPB5, RPB6, RPB7, RPB9,
CC       RPB10), a capping enzyme and a termination factor.
CC       {ECO:0000303|PubMed:32725217}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000305}. Virion
CC       {ECO:0000269|PubMed:30185597}. Note=Found in association with viral
CC       nucleoid. {ECO:0000269|PubMed:30185597}.
CC   -!- SIMILARITY: Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase
CC       subunit family. {ECO:0000305}.
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DR   EMBL; U18466; AAA65299.1; -; Genomic_DNA.
DR   RefSeq; NP_042763.1; NC_001659.2.
DR   SMR; P42484; -.
DR   GeneID; 22220299; -.
DR   KEGG; vg:22220299; -.
DR   Proteomes; UP000000624; Genome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.940.10; -; 1.
DR   InterPro; IPR020708; DNA-dir_RNA_polK_14-18kDa_CS.
DR   InterPro; IPR006110; Pol_omega/Rpo6/RPB6.
DR   InterPro; IPR036161; RPB6/omega-like_sf.
DR   InterPro; IPR006111; Rpo6/Rpb6.
DR   Pfam; PF01192; RNA_pol_Rpb6; 1.
DR   PIRSF; PIRSF000778; RpoK/RPB6; 1.
DR   SMART; SM01409; RNA_pol_Rpb6; 1.
DR   SUPFAM; SSF63562; SSF63562; 1.
DR   PROSITE; PS01111; RNA_POL_K_14KD; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Host cytoplasm; Reference proteome;
KW   Transcription; Viral transcription; Virion.
FT   CHAIN           1..147
FT                   /note="DNA-directed RNA polymerase RPB6 homolog"
FT                   /id="PRO_0000133805"
SQ   SEQUENCE   147 AA;  16691 MW;  6D0B66D77025CD45 CRC64;
     MADNDNEDII MDDLVEEYVE TEEENFVDSE EESEDKDEIV ESPSICEGFV QASSQTLVII
     PDNERITSNV LTTFEATRLV AVRAQQLAIN GSTMLKKKYS SPIDIAKQEL FNRKIPLLVM
     RCIKVTPEGQ KIVEIWNPRE MGIPLLD