ID   RPB7_RAT                Reviewed;         172 AA.
AC   P62489; P52433;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=DNA-directed RNA polymerase II subunit RPB7;
DE            Short=RNA polymerase II subunit B7;
DE   AltName: Full=DNA-directed RNA polymerase II subunit G;
GN   Name=Polr2g;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Sciatic nerve;
RA   Gillen C., Gleichmann M., Mueller H.;
RL   Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Component of RNA polymerase II which synthesizes mRNA precursors and
CC       many functional non-coding RNAs. Pol II is the central component of the
CC       basal RNA polymerase II transcription machinery. It is composed of
CC       mobile elements that move relative to each other. RPB7 is part of a
CC       subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and
CC       RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems
CC       to lock the clamp via RPB7 in the closed conformation thus preventing
CC       double-stranded DNA to enter the active site cleft. The RPB4-RPB7
CC       subcomplex binds single-stranded DNA and RNA. Binds RNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase II (Pol II) complex consisting
CC       of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the
CC       10-subunit Pol II core complex.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit
CC       family. {ECO:0000305}.
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DR   EMBL; Z71925; CAA96468.1; -; mRNA.
DR   EMBL; BC060550; AAH60550.1; -; mRNA.
DR   EMBL; BC060595; AAH60595.1; -; mRNA.
DR   RefSeq; NP_446400.1; NM_053948.4.
DR   RefSeq; XP_006231035.1; XM_006230973.1.
DR   AlphaFoldDB; P62489; -.
DR   SMR; P62489; -.
DR   BioGRID; 250618; 1.
DR   STRING; 10116.ENSRNOP00000026313; -.
DR   jPOST; P62489; -.
DR   PaxDb; P62489; -.
DR   Ensembl; ENSRNOT00000026313; ENSRNOP00000026313; ENSRNOG00000019439.
DR   GeneID; 117017; -.
DR   KEGG; rno:117017; -.
DR   UCSC; RGD:621284; rat.
DR   CTD; 5436; -.
DR   RGD; 621284; Polr2g.
DR   eggNOG; KOG3298; Eukaryota.
DR   GeneTree; ENSGT00390000008975; -.
DR   HOGENOM; CLU_085878_2_0_1; -.
DR   InParanoid; P62489; -.
DR   OMA; MRQPGLG; -.
DR   OrthoDB; 1140388at2759; -.
DR   PhylomeDB; P62489; -.
DR   TreeFam; TF103042; -.
DR   Reactome; R-RNO-112382; Formation of RNA Pol II elongation complex.
DR   Reactome; R-RNO-113418; Formation of the Early Elongation Complex.
DR   Reactome; R-RNO-5578749; Transcriptional regulation by small RNAs.
DR   Reactome; R-RNO-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-RNO-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-RNO-6782135; Dual incision in TC-NER.
DR   Reactome; R-RNO-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-RNO-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR   Reactome; R-RNO-6803529; FGFR2 alternative splicing.
DR   Reactome; R-RNO-6807505; RNA polymerase II transcribes snRNA genes.
DR   Reactome; R-RNO-72086; mRNA Capping.
DR   Reactome; R-RNO-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-RNO-72165; mRNA Splicing - Minor Pathway.
DR   Reactome; R-RNO-72203; Processing of Capped Intron-Containing Pre-mRNA.
DR   Reactome; R-RNO-73776; RNA Polymerase II Promoter Escape.
DR   Reactome; R-RNO-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR   Reactome; R-RNO-75953; RNA Polymerase II Transcription Initiation.
DR   Reactome; R-RNO-75955; RNA Polymerase II Transcription Elongation.
DR   Reactome; R-RNO-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR   Reactome; R-RNO-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR   Reactome; R-RNO-9018519; Estrogen-dependent gene expression.
DR   PRO; PR:P62489; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000019439; Expressed in thymus and 20 other tissues.
DR   Genevisible; P62489; RN.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0005665; C:RNA polymerase II, core complex; ISS:UniProtKB.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEP:RGD.
DR   GO; GO:0000291; P:nuclear-transcribed mRNA catabolic process, exonucleolytic; IBA:GO_Central.
DR   GO; GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; IBA:GO_Central.
DR   GO; GO:0045948; P:positive regulation of translational initiation; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.30.1490.120; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR036898; RNA_pol_Rpb7-like_N_sf.
DR   InterPro; IPR045113; Rpb7-like.
DR   InterPro; IPR005576; Rpb7-like_N.
DR   InterPro; IPR022967; S1_dom.
DR   InterPro; IPR003029; S1_domain.
DR   PANTHER; PTHR12709; PTHR12709; 1.
DR   Pfam; PF00575; S1; 1.
DR   Pfam; PF03876; SHS2_Rpb7-N; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF88798; SSF88798; 1.
PE   2: Evidence at transcript level;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; RNA-binding;
KW   Transcription.
FT   CHAIN           1..172
FT                   /note="DNA-directed RNA polymerase II subunit RPB7"
FT                   /id="PRO_0000073988"
SQ   SEQUENCE   172 AA;  19294 MW;  AF3CE655F658CD5C CRC64;
     MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT IDNIGAGVIQ
     PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE IGPMSCFISR HSIPSEMEFD
     PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT RVDKNDIFAI GSLMDDYLGL VS