ID   RPC10_BOVIN             Reviewed;         108 AA.
AC   Q2M2S7;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA-directed RNA polymerase III subunit RPC10;
DE            Short=RNA polymerase III subunit C10;
DE   AltName: Full=DNA-directed RNA polymerase III subunit K;
DE   AltName: Full=RNA polymerase III subunit C11;
DE            Short=RPC11;
GN   Name=POLR3K;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Component of RNA polymerase III which synthesizes small RNAs, such as
CC       5S rRNA and tRNAs. Plays a key role in sensing and limiting infection
CC       by intracellular bacteria and DNA viruses. Acts as nuclear and
CC       cytosolic DNA sensor involved in innate immune response. Can sense non-
CC       self dsDNA that serves as template for transcription into dsRNA. The
CC       non-self RNA polymerase III transcripts induce type I interferon and
CC       NF-kappa-B through the RIG-I pathway (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y2Y1}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. {ECO:0000250|UniProtKB:Q9Y2Y1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P32529}.
CC   -!- SIMILARITY: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11
CC       RNA polymerase family. {ECO:0000305}.
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DR   EMBL; BC111667; AAI11668.1; -; mRNA.
DR   RefSeq; NP_001040082.1; NM_001046617.2.
DR   AlphaFoldDB; Q2M2S7; -.
DR   SMR; Q2M2S7; -.
DR   STRING; 9913.ENSBTAP00000026386; -.
DR   PaxDb; Q2M2S7; -.
DR   PRIDE; Q2M2S7; -.
DR   GeneID; 618296; -.
DR   KEGG; bta:618296; -.
DR   CTD; 51728; -.
DR   eggNOG; KOG2906; Eukaryota.
DR   InParanoid; Q2M2S7; -.
DR   OrthoDB; 1508693at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0042779; P:tRNA 3'-trailer cleavage; IEA:InterPro.
DR   CDD; cd10509; Zn-ribbon_RPC11; 1.
DR   InterPro; IPR019761; DNA-dir_RNA_pol-M_15_CS.
DR   InterPro; IPR001529; DNA-dir_RNA_pol_M/15kDasu.
DR   InterPro; IPR012164; Rpa12/Rpb9/Rpc10/TFS.
DR   InterPro; IPR034014; Zn_ribbon_RPC11_C.
DR   InterPro; IPR001222; Znf_TFIIS.
DR   PANTHER; PTHR11239; PTHR11239; 1.
DR   Pfam; PF02150; RNA_POL_M_15KD; 1.
DR   Pfam; PF01096; TFIIS_C; 1.
DR   PIRSF; PIRSF005586; RNApol_RpoM; 1.
DR   SMART; SM00661; RPOL9; 1.
DR   SMART; SM00440; ZnF_C2C2; 1.
DR   PROSITE; PS01030; RNA_POL_M_15KD; 1.
DR   PROSITE; PS51133; ZF_TFIIS_2; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; DNA-directed RNA polymerase; Immunity; Innate immunity;
KW   Metal-binding; Nucleus; Reference proteome; Transcription; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..108
FT                   /note="DNA-directed RNA polymerase III subunit RPC10"
FT                   /id="PRO_0000244734"
FT   ZN_FING         5..28
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         65..107
FT                   /note="TFIIS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         69
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         72
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         97
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT   BINDING         102
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
SQ   SEQUENCE   108 AA;  12422 MW;  7476176504972BD5 CRC64;
     MLLFCPGCGN GLIVEEGQRC HRFACNTCPY VHNVTRKVTN RKYPKLKEVD DELGGAAAWE
     NVDSTAEPCP KCEHPRAYFM QLQTRYADEP MTTFYKCCNA QCGHRWRD