ID   RPC1_BPP1               Reviewed;         283 AA.
AC   P13121;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Repressor protein C1;
GN   Name=C1;
OS   Escherichia phage P1 (Bacteriophage P1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Punavirus.
OX   NCBI_TaxID=2886926;
OH   NCBI_TaxID=543; Enterobacteriaceae.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=KC;
RX   PubMed=2678003; DOI=10.1093/nar/17.19.7671;
RA   Osborne F.A., Stovall S.R., Baumstark B.R.;
RT   "The c1 genes of P1 and P7.";
RL   Nucleic Acids Res. 17:7671-7680(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-75.
RX   PubMed=3430609; DOI=10.1016/0022-2836(87)90313-5;
RA   Eliason J.L., Sternberg N.;
RT   "Characterization of the binding sites of c1 repressor of bacteriophage P1.
RT   Evidence for multiple asymmetric sites.";
RL   J. Mol. Biol. 198:281-293(1987).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-6; 25-42; 51-63; 68-77; 80-89; 91-93; 95-107;
RP   123-143; 149-182; 203-212; 235-242; 247-255 AND 257-267, CHARACTERIZATION,
RP   AND TEMPERATURE-SENSITIVE MUTANTS P1C1/100 AND P1C1/162.
RX   PubMed=2678004; DOI=10.1093/nar/17.19.7681;
RA   Heinrich J., Riedel H.D., Baumstark B.R., Kimura M., Schuster H.;
RT   "The c1 repressor of bacteriophage P1 operator-repressor interaction of
RT   wild-type and mutant repressor proteins.";
RL   Nucleic Acids Res. 17:7681-7692(1989).
CC   -!- FUNCTION: Sequence-specific DNA-binding protein required for the
CC       establishment and maintenance of lysogeny. This protein recognizes the
CC       sequence 5'-ATTTATTAGAGCA[AT]T-3'. Binding to the operator DNA of c1
CC       repressor is sensitive to N-ethylmaleimide.
CC   -!- MISCELLANEOUS: Thermolability of the mutant P1c1.100 seems to be due to
CC       an alteration in the C-terminal half of the repressor.
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DR   EMBL; X16005; CAA34143.1; -; Genomic_DNA.
DR   EMBL; X06561; CAA29807.1; -; Genomic_DNA.
DR   PIR; S06182; S06182.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR016726; Repressor_C1.
DR   PIRSF; PIRSF018461; Phage_repressor_C1; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..283
FT                   /note="Repressor protein C1"
FT                   /id="PRO_0000165238"
FT   DNA_BIND        30..49
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   REGION          254..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         55
FT                   /note="I -> S (in mutant P1c1.100)"
SQ   SEQUENCE   283 AA;  32515 MW;  D7FAA53264A0B40C CRC64;
     MINYVYGEQL YQEFVSFRDL FLKKAVARAQ HVDAASDGRP VRPVVVLPFK ETDSIQAEID
     KWTLMARELE QYPDLNIPKT ILYPVPNILR GVRKVTTYQT EAVNSVNMTA GRIIHLIDKD
     IRIQKSAGIN EHSAKYIENL EATKELMKQY PEDEKFRMRV HGFSETMLRV HYISSSPNYN
     DGKSVSYHVL LCGVFICDET LRDGIIINGE FEKAKFSLYD SIEPIICDRW PQAKIYRLAD
     IENVKKQIAI TREEKKVKSA ASVTRSRKTK KGQPVNDNPE SAQ