ID   RPC3_AJECN              Reviewed;         649 AA.
AC   A6R9K6;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=DNA-directed RNA polymerase III subunit rpc3;
DE            Short=RNA polymerase III subunit C3;
GN   Name=RPC82; Synonyms=RPC3; ORFNames=HCAG_06997;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific core component of RNA polymerase III which synthesizes small
CC       RNAs, such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476660; EDN09830.1; -; Genomic_DNA.
DR   RefSeq; XP_001539392.1; XM_001539342.1.
DR   AlphaFoldDB; A6R9K6; -.
DR   SMR; A6R9K6; -.
DR   STRING; 339724.A6R9K6; -.
DR   EnsemblFungi; EDN09830; EDN09830; HCAG_06997.
DR   GeneID; 5445702; -.
DR   KEGG; aje:HCAG_06997; -.
DR   VEuPathDB; FungiDB:HCAG_06997; -.
DR   HOGENOM; CLU_023294_0_0_1; -.
DR   OMA; QLKMVNE; -.
DR   OrthoDB; 809282at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005666; C:RNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR   InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR   InterPro; IPR039748; RPC3.
DR   InterPro; IPR024550; TFIIEa/SarR/Rpc3_HTH_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12949; PTHR12949; 1.
DR   Pfam; PF08221; HTH_9; 1.
DR   Pfam; PF05645; RNA_pol_Rpc82; 1.
DR   Pfam; PF02002; TFIIE_alpha; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription;
KW   Zinc.
FT   CHAIN           1..649
FT                   /note="DNA-directed RNA polymerase III subunit rpc3"
FT                   /id="PRO_0000351021"
FT   REGION          135..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          266..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          409..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          576..597
FT                   /note="Leucine-zipper"
FT   COMPBIAS        152..169
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   649 AA;  73570 MW;  9B1A4B9A37563CFB CRC64;
     MSQYAAELCK LLITDNFGEL YAPLPRIVQN TRLSPRQVRH GLAVLIQQRL IYHYTSLDDG
     IAYYEASWMT AYNLVRSGRI LQLVEEKLGK YVAKVLSTIL YHGHVRISYL ETLPELRPQV
     SSKAGKLVAA NGLNGIHSDE EEEEEDAHVT DQGEQEEYAS GRPENSVDSD YGKRSASQLH
     PALRSLAAYG YIMRVRDAHF QSPADLVEDA ERAVSSRSDV RGLKGKKFQE AIDAGVETYI
     KEKTDGTIPQ GPLAGALPRG IKRRAGQLAT NSSSKRVKLE HLPEGDEDID DDDFYGDDYV
     DGDNTLMDPN MIISVNYQKF EVALRNRRLA RLAEQCTSRV TSQVYEALLG RIELKTPACR
     KQPERVPEGE ENEQYSVAIP LHTILDDIDP DLDLSESMAG VDPANLLSNG HMGLNGDGNG
     DDDDDESTGA STGIWNRRRN RVYELEQHLS LLAQEPNIFS TRSMQSGMIT WAVEFRHLAR
     RLRHLEIERI IESRFGTIAV RVIRVLAAKG KLDEKRLQEI SLMASKELRQ VLARMEAAGF
     VDLQEVPRDA QRQPSRTMYL WFFDLDRVAR MVLEDTYKCM SRCLQRIGVE RNKLKLFLEK
     TERTDVKGNE EKYLSPAELK TLKEWRDKEA LLLGEVGRLD ELVSVLRDY