ID   RPC3_ASHGO              Reviewed;         636 AA.
AC   Q758N7;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=DNA-directed RNA polymerase III subunit RPC3;
DE            Short=RNA polymerase III subunit C3;
GN   Name=RPC82; Synonyms=RPC3; OrderedLocusNames=AEL282W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific core component of RNA polymerase III which synthesizes small
CC       RNAs, such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000305}.
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DR   EMBL; AE016818; AAS52402.1; -; Genomic_DNA.
DR   RefSeq; NP_984578.1; NM_209931.1.
DR   AlphaFoldDB; Q758N7; -.
DR   SMR; Q758N7; -.
DR   STRING; 33169.AAS52402; -.
DR   EnsemblFungi; AAS52402; AAS52402; AGOS_AEL282W.
DR   GeneID; 4620758; -.
DR   KEGG; ago:AGOS_AEL282W; -.
DR   eggNOG; KOG2587; Eukaryota.
DR   HOGENOM; CLU_010734_0_0_1; -.
DR   InParanoid; Q758N7; -.
DR   OMA; QLKMVNE; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0001056; F:RNA polymerase III activity; IEA:EnsemblFungi.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0006386; P:termination of RNA polymerase III transcription; IEA:EnsemblFungi.
DR   GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; IEA:EnsemblFungi.
DR   GO; GO:0042797; P:tRNA transcription by RNA polymerase III; IEA:EnsemblFungi.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR   InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR   InterPro; IPR039748; RPC3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12949; PTHR12949; 1.
DR   Pfam; PF08221; HTH_9; 1.
DR   Pfam; PF05645; RNA_pol_Rpc82; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription;
KW   Zinc.
FT   CHAIN           1..636
FT                   /note="DNA-directed RNA polymerase III subunit RPC3"
FT                   /id="PRO_0000351022"
FT   REGION          366..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          563..584
FT                   /note="Leucine-zipper"
SQ   SEQUENCE   636 AA;  71488 MW;  464490DEA335FD2B CRC64;
     MNGSMGAAGG QVENERAAEV PVSTLEMRTL SPETFLYTEV ARSHLGERAG RVIELLLNKG
     RLSVSELVHL APELGSKSVR TVLVSLIQLR CVQYLEETTV SGRKITYYYF NEDGFQLMLY
     AGDIVAAVES QFEADDAKEI AAQIVQNVLA LGSLTTKDYM QSLASDVSVN DVASMFVKLV
     ELGFLVPLSN VHYMPLADLW DVLYKKEYNA IPKNSTLSDA KKRAETKAKT KVQFNTLLKN
     VEMSNVLMTD MQTSMRRVQD NLPLTFNFGR YMKHRRSRQL VQFARSRVGS VPAMIYKVAL
     KITEQCARAL SDPLCETGLM QELEEQLAIQ EDMALDDEKL PGVTFNAVDI SRNLPNNIDL
     RGTLTSMQRR SQERSTHQGQ SHKRLKAEDG MAVAVNHLAT VEEEAEGDEL LHGSDDDMDM
     FFDEGDSDPK SVSLINGHLK LLSTGSVPFL IESRPGLFYV PYSKLMPILK EAVYDAIIAS
     TLGPSAHRIL RCVRDNSLVS EKVINNTALM REKDIRSVIA TLVKYNAVDI LEVPRTADRA
     ASRAVFLFKI NEKHAYDFMK QNLAWNIANS IHKTEILKEE NFTLLSKAQR DDVKGREAEL
     LLPSELNQLK MVNERELNGH ARKIRLLSMW EVFKML