ID   RPC3_ASPFU              Reviewed;         629 AA.
AC   Q4WEU2;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA-directed RNA polymerase III subunit rpc3;
DE            Short=RNA polymerase III subunit C3;
GN   Name=rpc82; Synonyms=rpc3; ORFNames=AFUA_5G04200;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific core component of RNA polymerase III which synthesizes small
CC       RNAs, such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000305}.
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DR   EMBL; AAHF01000011; EAL85885.1; -; Genomic_DNA.
DR   RefSeq; XP_747923.1; XM_742830.1.
DR   AlphaFoldDB; Q4WEU2; -.
DR   SMR; Q4WEU2; -.
DR   STRING; 746128.CADAFUBP00005161; -.
DR   EnsemblFungi; EAL85885; EAL85885; AFUA_5G04200.
DR   GeneID; 3505557; -.
DR   KEGG; afm:AFUA_5G04200; -.
DR   eggNOG; KOG2587; Eukaryota.
DR   HOGENOM; CLU_023294_0_0_1; -.
DR   InParanoid; Q4WEU2; -.
DR   OMA; QLKMVNE; -.
DR   OrthoDB; 809282at2759; -.
DR   Proteomes; UP000002530; Chromosome 5.
DR   GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR   InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR   InterPro; IPR039748; RPC3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12949; PTHR12949; 1.
DR   Pfam; PF08221; HTH_9; 1.
DR   Pfam; PF05645; RNA_pol_Rpc82; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription;
KW   Zinc.
FT   CHAIN           1..629
FT                   /note="DNA-directed RNA polymerase III subunit rpc3"
FT                   /id="PRO_0000351024"
FT   REGION          136..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          373..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          556..577
FT                   /note="Leucine-zipper"
FT   COMPBIAS        138..156
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..274
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        275..293
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..405
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   629 AA;  71709 MW;  269C05C0EAACDE76 CRC64;
     MTSQFAAELC ELLVEENFGE LFGRIFATLS RYDRLNLPRL KAYSELPNRQ LLPALAAMIQ
     QHLVYHYTSY DDGVTYYEAN MQSAYYLVRS GKILEFVEER LGKYAATVLS TIMYLGHAQV
     SYLETLPELT SEAVKANGVP EEHGEHEEDE EQSNGLNGEH SNEQPELLHP TLKALAAHGY
     IIRVREAQFQ SHADNILDAE RAIRSKPEMK ALKGKRLEEA VIEGTLGLLK ERTDGDLTRG
     LIVHGVPRGA KRKHSSRRAD EPNKKCRTDF ASVDENDEHD EEEENEWSDD EMGYDTTPME
     VSARELYATV SERETEQGVS PATAKVYECL LRRIEYQTHQ CRDTAEIPRE GEEGEQYSVP
     IALSALAEDV NPQLDLSSST GPMDSSQPDG RRGKRPWDGD VEGTNHEEAN GLSSGGSGGN
     RTFEIDQHLS LLAQPPHNLT SKRMVSGLIT WTVEFRHLAR KLRHLELERM IEARYGDVAL
     RVVRVLHAKG KLDEKRLQEI SLLPFKDLRQ VLASMQAGGF VDLQEVPRDA QRQPSRTIYL
     WYYDPDRICN SVLQDTYKAM SRCLQRLRFE RSRIKDFLEK TERSDVKGNE QRFLSEPELV
     LLEQWRAKEA LLLGEVARLD EMVAVMRDY