ID   RPC3_BOVIN              Reviewed;         533 AA.
AC   Q2TBL4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA-directed RNA polymerase III subunit RPC3;
DE            Short=RNA polymerase III subunit C3;
DE   AltName: Full=DNA-directed RNA polymerase III subunit C;
GN   Name=POLR3C;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific core component of RNA polymerase III which synthesizes small
CC       RNAs, such as 5S rRNA and tRNAs. May direct with other members of the
CC       subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the
CC       interactions between TFIIIB and POLR3F. May be involved either in the
CC       recruitment and stabilization of the subcomplex within RNA polymerase
CC       III, or in stimulating catalytic functions of other subunits during
CC       initiation. Plays a key role in sensing and limiting infection by
CC       intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic
CC       DNA sensor involved in innate immune response. Can sense non-self dsDNA
CC       that serves as template for transcription into dsRNA. The non-self RNA
CC       polymerase III transcripts induce type I interferon and NF-Kappa-B
CC       through the RIG-I pathway. Preferentially binds single-stranded DNA
CC       (ssDNA) in a sequence-independent manner.
CC       {ECO:0000250|UniProtKB:Q9BUI4}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and
CC       RPC7/POLR3G form a Pol III subcomplex (By similarity). Directly
CC       interacts with POLR3G and POLR3GL. Directly interacts with
CC       POLR3F/RPC39. Interacts with GTF3C4. {ECO:0000250|UniProtKB:Q9BUI4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase
CC       subunit family. {ECO:0000305}.
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DR   EMBL; BC109972; AAI09973.1; -; mRNA.
DR   RefSeq; NP_001033600.1; NM_001038511.1.
DR   AlphaFoldDB; Q2TBL4; -.
DR   SMR; Q2TBL4; -.
DR   STRING; 9913.ENSBTAP00000028832; -.
DR   PaxDb; Q2TBL4; -.
DR   PRIDE; Q2TBL4; -.
DR   Ensembl; ENSBTAT00000028832; ENSBTAP00000028832; ENSBTAG00000021637.
DR   GeneID; 507314; -.
DR   KEGG; bta:507314; -.
DR   CTD; 10623; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021637; -.
DR   VGNC; VGNC:33147; POLR3C.
DR   eggNOG; KOG2587; Eukaryota.
DR   GeneTree; ENSGT00390000002799; -.
DR   InParanoid; Q2TBL4; -.
DR   OMA; FETNECD; -.
DR   OrthoDB; 809282at2759; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000021637; Expressed in oocyte and 107 other tissues.
DR   ExpressionAtlas; Q2TBL4; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0045089; P:positive regulation of innate immune response; ISS:UniProtKB.
DR   GO; GO:0032728; P:positive regulation of interferon-beta production; ISS:UniProtKB.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 4.
DR   InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR   InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR   InterPro; IPR039748; RPC3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR12949; PTHR12949; 1.
DR   Pfam; PF08221; HTH_9; 1.
DR   Pfam; PF05645; RNA_pol_Rpc82; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; DNA-binding; DNA-directed RNA polymerase; Immunity;
KW   Innate immunity; Nucleus; Phosphoprotein; Reference proteome;
KW   Transcription.
FT   CHAIN           1..533
FT                   /note="DNA-directed RNA polymerase III subunit RPC3"
FT                   /id="PRO_0000254905"
FT   REGION          197..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..226
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         194
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BUI4"
SQ   SEQUENCE   533 AA;  60429 MW;  51348E56DAFD9566 CRC64;
     MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIA HDTGTSLDQV KKALCVLIQH
     NLVTYQVHKR GVVEYEAQCN RVLRMLRYPR YIYTAKTLYS DTGELIVEEL LLNGKMTMSA
     VVKKVADRLT ETMEDGKTMD YAEVSNTFVR LVDTHFVQRC PLVPATENSD TGPPPPAPTL
     VVSEKDMYLV PKLSLIGKGK RRRSSDEDAT GEPKAKRPKQ TTDNKEPIPD DGIYWQANLD
     RFHQHFRDQA IVSAVANRMD QTSSEIVRTM LRMSEVTTPS GAPFTQPLSS NEIFRSLPVG
     YNISKQVLDQ YLTLLADDPL EFVGKSGDSG GGMYVINLHK ALGSLATATL ESVVQERFGS
     RCARIFRLVL QKKHLEQKQV EDFAMIPAKE AKDMLYKMLS ENFISLQEIP KTPDHAPSRT
     FYLYTVNILS AARMLLHRCY KSVANLIERR QFETKENKRL LEKSQRVEAI IASMQATGAE
     EAQLQEIEEM ITAPERQQLE TLKRNVNKLD ACEIQVDETI FLLESYIEST MKR