ID   RPC3_CANAL              Reviewed;         595 AA.
AC   Q5A246; A0A1D8PSD1; Q5A1Z6;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=DNA-directed RNA polymerase III subunit RPC3;
DE            Short=RNA polymerase III subunit C3;
GN   Name=RPC82; Synonyms=RPC3; OrderedLocusNames=CAALFM_CR02890CA;
GN   ORFNames=CaO19.10366, CaO19.2847;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific core component of RNA polymerase III which synthesizes small
CC       RNAs, such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000305}.
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DR   EMBL; CP017630; AOW31029.1; -; Genomic_DNA.
DR   RefSeq; XP_715778.2; XM_710685.2.
DR   AlphaFoldDB; Q5A246; -.
DR   SMR; Q5A246; -.
DR   STRING; 237561.Q5A246; -.
DR   PRIDE; Q5A246; -.
DR   GeneID; 3642585; -.
DR   KEGG; cal:CAALFM_CR02890CA; -.
DR   CGD; CAL0000174854; orf19.10366.
DR   VEuPathDB; FungiDB:CR_02890C_A; -.
DR   eggNOG; KOG2587; Eukaryota.
DR   HOGENOM; CLU_010734_0_0_1; -.
DR   InParanoid; Q5A246; -.
DR   OrthoDB; 809282at2759; -.
DR   PRO; PR:Q5A246; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0001056; F:RNA polymerase III activity; IEA:EnsemblFungi.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IEA:UniProt.
DR   GO; GO:0006386; P:termination of RNA polymerase III transcription; IEA:EnsemblFungi.
DR   GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; IEA:EnsemblFungi.
DR   GO; GO:0042797; P:tRNA transcription by RNA polymerase III; IEA:EnsemblFungi.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR   InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR   InterPro; IPR039748; RPC3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12949; PTHR12949; 1.
DR   Pfam; PF08221; HTH_9; 1.
DR   Pfam; PF05645; RNA_pol_Rpc82; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription;
KW   Zinc.
FT   CHAIN           1..595
FT                   /note="DNA-directed RNA polymerase III subunit RPC3"
FT                   /id="PRO_0000351029"
FT   REGION          523..544
FT                   /note="Leucine-zipper"
SQ   SEQUENCE   595 AA;  68319 MW;  23DE3CF7069DCCC8 CRC64;
     MDEVQMETAR IQSPKSYLYT TLATTHLGEI ASCIISILIS NGRLTAREIS NRTKIPTKNI
     KSALVSLIQL NCIYYWQEEK DRKFYYSLKE TGLLLFVYSG DIINHIKRQY GEDEAEIIQN
     ILIHGHVKIE DYLTQFNHDK SMKIDQENKF LKLFNDNWLI KLQDYHFHSL DDIWHKIFEE
     CLKDTPRSSV TSEIKRVAEA QAKAKVKLNT LLESGTTGGG DIFTEVNGMK KLKPDLVVTF
     NLSRFQKHLR TNAFVNMVRS KIGVLTAIVY DAALRYIENK SPPMDYPLLD IPGLINDPKD
     VKEYILSIEN KLVNEKKITF SARDIQRLLP KDIDFKNSVI TPTFAKPKRP LENGSSPTLK
     KIKLEDGIAS STSTSTSTSS STSSNGTSID LNTLEQHLKL LLNGTNTAFV NEISPGNYTI
     PFSHLTNILK QNNFEALVKA TLGDYAFRIL RCVKSMKLCD EKSICNGALL KEKTVRSELY
     HLIKANIIEI QEVPRSADRA ASKTFYLFRH KSNSNFNYLK NCLIYDMAEI LNRIQDFKLE
     HKILLEKYKL VEGQEDQYLL DRELKLLNDL QLREIKNLVK FQRIKSLYSL YSLVD