ID   RPC3_COCIM              Reviewed;         653 AA.
AC   Q1DTR6; J3K8E2;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA-directed RNA polymerase III subunit RPC-3;
DE            Short=RNA polymerase III subunit C3;
GN   Name=RPC-82; Synonyms=RPC-3; ORFNames=CIMG_06297;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific core component of RNA polymerase III which synthesizes small
CC       RNAs, such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000305}.
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DR   EMBL; GG704912; EAS30818.3; -; Genomic_DNA.
DR   RefSeq; XP_001242401.1; XM_001242400.2.
DR   AlphaFoldDB; Q1DTR6; -.
DR   SMR; Q1DTR6; -.
DR   STRING; 246410.Q1DTR6; -.
DR   EnsemblFungi; EAS30818; EAS30818; CIMG_06297.
DR   GeneID; 4561612; -.
DR   KEGG; cim:CIMG_06297; -.
DR   VEuPathDB; FungiDB:CIMG_06297; -.
DR   InParanoid; Q1DTR6; -.
DR   OMA; QLKMVNE; -.
DR   OrthoDB; 809282at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005666; C:RNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR   InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR   InterPro; IPR039748; RPC3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR12949; PTHR12949; 1.
DR   Pfam; PF08221; HTH_9; 1.
DR   Pfam; PF05645; RNA_pol_Rpc82; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription;
KW   Zinc.
FT   CHAIN           1..653
FT                   /note="DNA-directed RNA polymerase III subunit RPC-3"
FT                   /id="PRO_0000351032"
FT   REGION          141..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          422..442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          580..601
FT                   /note="Leucine-zipper"
FT   COMPBIAS        151..172
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   653 AA;  74226 MW;  C67E758998504669 CRC64;
     MSQYAAELCK LLITDNFGEL YALIFIYLLN HGRQPLPRIV QNTHLSPRQV RHGLAVLVQQ
     HLVFHCTSLD DGITYYESNW RSAYNLVRSG KIIQLVEERL GNRAASIVST LLALGHAKIS
     YLESLPELQP GHERPVKANG INGVHGGEGE DVNGVDNDAE NHTDHAHDYQ QDGPVREPNG
     YHDSDPGLQV QTILQQLAAF GFITRVRNQH FQSPEDNFDA ALKAAKSNGD SYGLKGNKLE
     AKLTEDAEKL VKEWTDGRIS RALPSASLLR GVKRRLRKDD SSAPRKRLKL DGPLEDDVKD
     EDDGDDFSDD DYHNDEMAAL DPNMVIRVNY EKFNVALRNR RLIELADQNG SAVTSQVYET
     LLSHIEVQTP TCREHVEAIP EGEEAEQYSV SIRLDTISRD LDIDLDLAGV IAGIIPDNIN
     GIKEDEDDED EEGGPVSMKR RGPSRNYLVD QHLSFLAAEP SFFCTRRMQA GMITWAVEYR
     HLAKKLRHLE LERLIEARFG GFAVRIVRVL AAKGKLDEKR LQEISLMASK DLRQILGQMA
     SAGFVELQEV PRDAQRQPSR TMYLWFYDPD RVRFMVIEDT YKSMSRCLQR IRVEREKLKF
     LLEKTERSDV KGNEDRYLSA AELQTLKEWR DTEKLLLGEV ARLDELVAVL RDY