ID   RPC3_DANRE              Reviewed;         539 AA.
AC   Q7ZUX1;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA-directed RNA polymerase III subunit RPC3;
DE            Short=RNA polymerase III subunit C3;
DE   AltName: Full=DNA-directed RNA polymerase III subunit C;
GN   Name=polr3c; ORFNames=zgc:56348;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific core component of RNA polymerase III which synthesizes small
CC       RNAs, such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase
CC       subunit family. {ECO:0000305}.
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DR   EMBL; BC046092; AAH46092.1; -; mRNA.
DR   RefSeq; NP_956526.1; NM_200232.1.
DR   AlphaFoldDB; Q7ZUX1; -.
DR   SMR; Q7ZUX1; -.
DR   STRING; 7955.ENSDARP00000059966; -.
DR   PaxDb; Q7ZUX1; -.
DR   GeneID; 393201; -.
DR   KEGG; dre:393201; -.
DR   CTD; 10623; -.
DR   ZFIN; ZDB-GENE-040426-992; polr3c.
DR   eggNOG; KOG2587; Eukaryota.
DR   InParanoid; Q7ZUX1; -.
DR   OrthoDB; 809282at2759; -.
DR   PhylomeDB; Q7ZUX1; -.
DR   Reactome; R-DRE-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR   Reactome; R-DRE-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR   Reactome; R-DRE-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR   PRO; PR:Q7ZUX1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 4.
DR   InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR   InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR   InterPro; IPR039748; RPC3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR12949; PTHR12949; 1.
DR   Pfam; PF08221; HTH_9; 1.
DR   Pfam; PF05645; RNA_pol_Rpc82; 1.
PE   2: Evidence at transcript level;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..539
FT                   /note="DNA-directed RNA polymerase III subunit RPC3"
FT                   /id="PRO_0000073965"
FT   REGION          165..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..234
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   539 AA;  60489 MW;  8E4FDD6835A94354 CRC64;
     MTAQEVRLCG LLLQEHFGDV VENVGTHLIR NGVLTLRALA HETKLALDLV KKSLCVLVQH
     GMCTFGPGRR GPAGPVEYHI NCEHILHMLR YPRYIYTAKS LYGDTGELIV EEILQRGQMT
     MSSTVKTVAD RLTHNMPEGQ SMDYNEVVSA FSRLVETHFL QRCPPMASAE SSGTGSAETP
     PAVTQPSNPE SHPDCYKLPY ISLSGHGKRR RSSEDGEADQ RAAKKAKTDS SECGDEGIHW
     QVNFERFHLH FRDQAIISAV SCKLDQTSGE IVRTMLRMSE VTTSANAAFT QALSANEIFR
     ALPSNYNIAR PILDQYLTLL VDDPMEFVGK AGDSGGGMFV VNLHRALANL ARATLESVVQ
     ERFGSRSARI FRLLLRKRHL EQKQVEDFAM IPAKEAKEML YTLLSENLVQ LQEIPKTPDH
     APSRTFYLYA VNQLPTARLL LQHCYKTVGN LIERRLYETK ENKRLLEKSQ RIEAILASLQ
     ATGAEATQLT EVEEMITAPE RQQLESLRHH INKLDSGENQ VDETIFLLES YINSTQASR