ID   RPC3_NEOFI              Reviewed;         655 AA.
AC   A1CZP6;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DNA-directed RNA polymerase III subunit rpc3;
DE            Short=RNA polymerase III subunit C3;
GN   Name=rpc82; Synonyms=rpc3; ORFNames=NFIA_037900;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific core component of RNA polymerase III which synthesizes small
CC       RNAs, such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000305}.
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DR   EMBL; DS027686; EAW24216.1; -; Genomic_DNA.
DR   RefSeq; XP_001266113.1; XM_001266112.1.
DR   AlphaFoldDB; A1CZP6; -.
DR   SMR; A1CZP6; -.
DR   STRING; 36630.CADNFIAP00003527; -.
DR   EnsemblFungi; EAW24216; EAW24216; NFIA_037900.
DR   GeneID; 4592324; -.
DR   KEGG; nfi:NFIA_037900; -.
DR   VEuPathDB; FungiDB:NFIA_037900; -.
DR   eggNOG; KOG2587; Eukaryota.
DR   HOGENOM; CLU_023294_0_0_1; -.
DR   OMA; QLKMVNE; -.
DR   OrthoDB; 809282at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005666; C:RNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR   InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR   InterPro; IPR039748; RPC3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12949; PTHR12949; 1.
DR   Pfam; PF08221; HTH_9; 1.
DR   Pfam; PF05645; RNA_pol_Rpc82; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription;
KW   Zinc.
FT   CHAIN           1..655
FT                   /note="DNA-directed RNA polymerase III subunit rpc3"
FT                   /id="PRO_0000351037"
FT   REGION          153..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          402..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          582..603
FT                   /note="Leucine-zipper"
FT   COMPBIAS        157..173
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..292
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        417..431
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   655 AA;  74697 MW;  591F0F9B8DAC29DE CRC64;
     MRQATELDQS IHCASAANLD LVQFAAELCE LLVEENFGEL FGRIFATLSR YDRLNLPRLK
     AYSELPNRQL LPALAAMIQQ HLVYHYTSYD DGVTYYEANM QSAYYLVRSG KILEFVEERL
     GKYAATVLST IMNLGHAQVS YLETLPELTS EAVKANGVSE EHGEHEEGEE QSNGLNGEHS
     NEQPELLHPT LKALAAHGYI IRVREAQFQS HADNILDAER VIRSKPEMKA LKGKRLEEAV
     IEGTLGLLKE RTDGDLTRGL IVHGVPRGAK RKYSSRRADE PNKKPRTDFA SVDEIDEQDE
     EEENEWLDDE MGYDTTPMES GLVVRVNYNK LDVALRNRRF IELAEQGVSP ETAEVYECLL
     RRIEYQTHQC RDTAEIPREG EEGEQYSVPI ALSALAEDVD PRLDLSSSTG PMDTSQPDGR
     RGKRPLESDV DGTNHEGANG LSSGGNRTFE IDQHLSLLAQ PPHNLTSKRM VSGLITWTVE
     FRHLARKLRH LELERMIEAR YGDVALRVVR VLHAKGKLDE KRLQEISLLP FKDLRQVLAS
     MQAGGFVDLQ EVPRDAQRQP SRTIYLWYYD PDRICNSVLQ DTYKAMSRCL QRLRFERSRI
     KDFLEKTERS DVKGNEQRFL SEPELVLLEQ WRAKEALLLG EVARLDEMVA VMRDY