ID   RPC3_NEUCR              Reviewed;         624 AA.
AC   Q8WZW7;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA-directed RNA polymerase III subunit rpc-3;
DE            Short=RNA polymerase III subunit C3;
GN   Name=rpc-82; Synonyms=rpc-3; ORFNames=B7N14.090, NCU03560;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific core component of RNA polymerase III which synthesizes small
CC       RNAs, such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000305}.
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DR   EMBL; AL669986; CAD21045.1; -; Genomic_DNA.
DR   EMBL; CM002237; EAA26887.1; -; Genomic_DNA.
DR   RefSeq; XP_956123.1; XM_951030.2.
DR   AlphaFoldDB; Q8WZW7; -.
DR   SMR; Q8WZW7; -.
DR   STRING; 5141.EFNCRP00000002678; -.
DR   EnsemblFungi; EAA26887; EAA26887; NCU03560.
DR   GeneID; 3872278; -.
DR   KEGG; ncr:NCU03560; -.
DR   VEuPathDB; FungiDB:NCU03560; -.
DR   HOGENOM; CLU_023294_0_0_1; -.
DR   InParanoid; Q8WZW7; -.
DR   OMA; QLKMVNE; -.
DR   Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR   GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 3.
DR   InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR   InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR   InterPro; IPR039748; RPC3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR12949; PTHR12949; 1.
DR   Pfam; PF08221; HTH_9; 1.
DR   Pfam; PF05645; RNA_pol_Rpc82; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription;
KW   Zinc.
FT   CHAIN           1..624
FT                   /note="DNA-directed RNA polymerase III subunit rpc-3"
FT                   /id="PRO_0000351038"
FT   REGION          229..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          373..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          551..572
FT                   /note="Leucine-zipper"
FT   COMPBIAS        384..399
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..414
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  70925 MW;  600F8D4356495A0E CRC64;
     MAVIKEKAEC CTLLVDELYG QLPARVYATL FQRGKLSVRL ISQFSKLSAR QVKNGLCVLQ
     QHNLLFYSVD ANSGEAEYSV NHEYAYNLVR TGKILEMVDN SYGPAGRDVM QNLLLLGQTR
     ISDLVAAYQA KINEVNNDDA WLNDKKPELA IKSKAQLNSV LCRLIEAELI DVIHSKTFQS
     AHEIEKQVHR EVMDVYFSNG IKGTKAKIEF EQRVAEGLRK VREESKTLKR KLAQNGGASK
     RRKLAVGNET NGAPEEEEDL DPALDPRQVI RINYEKCIVE LRSRRLVQYV NETLGETTGY
     VYGQLLKQLT KNISRCKSDP LIDALTPEEK VTPSVTTNEI LDKVKTSIDL TLGIGKIPSK
     SISKSAAERL TPLAPKDKIP FMNQDDSDDD EEDGDYSDSD EEMDTKKENG DAPVARMSRP
     EQLRQHLLLL AEGHPGFVRH CGEDEWTVDF KPLMENLRAT ELDSIIEQTS GRQGLRLIRI
     LRTKGKLGEQ ALQSLSLMRK VDLQQKMLEM RLVGFAHTQE VPRDNKADPK KSIFLWYCDT
     EQAYSSLIAK CYATMVHCLQ VLEVRRQKDK DVLSLAKRTN VKGKEKDMMR DESYARFAKF
     LKDERLLMAE MMRIDDTLAL LQDY