ID   RPC3_PICGU              Reviewed;         588 AA.
AC   A5DQA6;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=DNA-directed RNA polymerase III subunit RPC3;
DE            Short=RNA polymerase III subunit C3;
GN   Name=RPC82; Synonyms=RPC3; ORFNames=PGUG_05457;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific core component of RNA polymerase III which synthesizes small
CC       RNAs, such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH408161; EDK41359.2; -; Genomic_DNA.
DR   RefSeq; XP_001482437.1; XM_001482387.1.
DR   AlphaFoldDB; A5DQA6; -.
DR   SMR; A5DQA6; -.
DR   STRING; 4929.XP_001482437.1; -.
DR   EnsemblFungi; EDK41359; EDK41359; PGUG_05457.
DR   GeneID; 5124150; -.
DR   KEGG; pgu:PGUG_05457; -.
DR   VEuPathDB; FungiDB:PGUG_05457; -.
DR   eggNOG; KOG2587; Eukaryota.
DR   HOGENOM; CLU_010734_0_0_1; -.
DR   InParanoid; A5DQA6; -.
DR   OMA; QLKMVNE; -.
DR   OrthoDB; 809282at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005666; C:RNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR   InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR   InterPro; IPR039748; RPC3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12949; PTHR12949; 1.
DR   Pfam; PF08221; HTH_9; 1.
DR   Pfam; PF05645; RNA_pol_Rpc82; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription;
KW   Zinc.
FT   CHAIN           1..588
FT                   /note="DNA-directed RNA polymerase III subunit RPC3"
FT                   /id="PRO_0000351039"
FT   REGION          516..537
FT                   /note="Leucine-zipper"
SQ   SEQUENCE   588 AA;  66973 MW;  60AACDB38A3B172A CRC64;
     MTYLEALRTA RVQSPQSYLY TTVARMHLGS VAAVCISILI SSGRMTVKQL SSKAGIPVKT
     VKTTLVSLIQ LRCVQYWREE GSGRVLYSFN EEGIWILLQS GEIINWIRCE YGEEEAEIIQ
     NILEIGHIKV ADYLTNFEDQ KRHDREIILM RLYSDKWLRR LQPFNFNPLA DIWEAKYEET
     IRSIPRTNTT SEIKRVTEAK EQTKRKIIDL FQSADDPNVV FTVKDGIKKL NPNITISFNL
     ARFEKHLRSE ALFHLAKYKV GTLTAKVYET ALKLVEANSP DLNPQFLSIS GWCADPEEVK
     SYKNSIENKL VDDRKITFGV RDVARALPED LDLSCSILTH NFLKPTKRAS DGANGAASKK
     VKLEDGESLD VFVENLEKND SQSSSLILHH LKALCSGTNI SFLHETSPSN FTIPYSALVD
     ELKKHHYDLL IKITLGPNAF RVLRALKSLK LADEKALANA VLLKEKTLRN EIFNMVNLNI
     VEIQEVPRSA DRAASKTFFL FRHKEQTAYN FLINSLTFGM AELLQGIVDF KDEHRILLAK
     CEREDVKGNE ESLLLASELK TLKTLQEREM VSIARFSRLK ALRQVFSA