ID   RPC3_YEAS7              Reviewed;         654 AA.
AC   A6ZX64;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=DNA-directed RNA polymerase III subunit RPC3;
DE            Short=RNA polymerase III subunit C3;
DE   AltName: Full=C82;
DE   AltName: Full=DNA-directed III 74 kDa polypeptide;
DE            Short=C74;
GN   Name=RPC82; Synonyms=RPC3; ORFNames=SCY_5891;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific core component of RNA polymerase III which synthesizes small
CC       RNAs, such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFW02000135; EDN61306.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZX64; -.
DR   SMR; A6ZX64; -.
DR   PRIDE; A6ZX64; -.
DR   EnsemblFungi; EDN61306; EDN61306; SCY_5891.
DR   HOGENOM; CLU_010734_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005666; C:RNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR   InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR   InterPro; IPR039748; RPC3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR12949; PTHR12949; 1.
DR   Pfam; PF08221; HTH_9; 1.
DR   Pfam; PF05645; RNA_pol_Rpc82; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-directed RNA polymerase; Nucleus; Phosphoprotein;
KW   Transcription.
FT   CHAIN           1..654
FT                   /note="DNA-directed RNA polymerase III subunit RPC3"
FT                   /id="PRO_0000351043"
FT   REGION          381..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          422..448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          581..602
FT                   /note="Leucine-zipper"
FT   COMPBIAS        429..444
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         27
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P32349"
FT   MOD_RES         392
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P32349"
FT   MOD_RES         394
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P32349"
SQ   SEQUENCE   654 AA;  73987 MW;  026F20D13A1D2C43 CRC64;
     MDELLGEALS AENQAGESTV ESEKLVTPED VMTISSLEQR TLNPDLFLYK ELVKAHLGER
     AASVIGMLVA LGRLSVRELV EKIDGMDVDS VKTTLVSLTQ LRCVKYLQET AISGKKTTYY
     YYNEEGIHIL LYSGLIIDEI ITQMRVNDEE EHKQLVAEIV QNVISLGSLT VEDYLSSVTS
     DSMKYTISSL FVQLCEMGYL IQISKLHYTP IEDLWQFLYE KHYKNIPRNS PLSDLKKRSQ
     AKMNAKTDFA KIINKPNELS QILTVDPKTS LRIVKPTVSL TINLDRFMKG RRSKQLINLA
     KTRVGSVTAQ VYKIALRLTE QKSPKIRDPL TQTGLLQDLE EAKSFQDEAE LVEEKTPGLT
     FNAIDLARHL PAELDLRGSL LSRKPSDNKK RSGSNAAASL PSKKLKTEDG FVIPALPAAV
     SKSLQESGDT QEEDEEEEDL DADTEDPHSA SLINSHLKIL ASSNFPFLNE TKPGVYYVPY
     SKLMPVLKSS VYEYVIASTL GPSAMRLSRC IRDNKLVSEK IINSTALMKE KDIRSTLASL
     IRYNSVEIQE VPRTADRSAS RAVFLFRCKE THSYNFMRQN LEWNMANLLF KKEKLKQENS
     TLLKKANRDD VKGRENELLL PSELNQLKMV NERELNVFAR LSRLLSLWEV FQMA