RPC4_BOVIN
ID RPC4_BOVIN Reviewed; 398 AA.
AC Q5E9Z7; Q17QS2;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=DNA-directed RNA polymerase III subunit RPC4;
DE Short=RNA polymerase III subunit C4;
DE AltName: Full=DNA-directed RNA polymerase III subunit D;
GN Name=POLR3D;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Specific peripheric component of RNA polymerase III which synthesizes
CC small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and
CC limiting infection by intracellular bacteria and DNA viruses. Acts as
CC nuclear and cytosolic DNA sensor involved in innate immune response.
CC Can sense non-self dsDNA that serves as template for transcription into
CC dsRNA. The non-self RNA polymerase III transcripts induce type I
CC interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC consisting of 17 subunits. Interacts with RPC5 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPC4/POLR3D RNA polymerase
CC subunit family. {ECO:0000305}.
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DR EMBL; BT020772; AAX08789.1; -; mRNA.
DR EMBL; BC118212; AAI18213.1; -; mRNA.
DR RefSeq; XP_005210298.1; XM_005210241.3.
DR RefSeq; XP_005210299.1; XM_005210242.3.
DR AlphaFoldDB; Q5E9Z7; -.
DR STRING; 9913.ENSBTAP00000013251; -.
DR PaxDb; Q5E9Z7; -.
DR PRIDE; Q5E9Z7; -.
DR GeneID; 508049; -.
DR CTD; 661; -.
DR eggNOG; KOG3122; Eukaryota.
DR InParanoid; Q5E9Z7; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0045089; P:positive regulation of innate immune response; ISS:UniProtKB.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; ISS:UniProtKB.
DR GO; GO:0006383; P:transcription by RNA polymerase III; IEA:InterPro.
DR InterPro; IPR007811; RPC4.
DR PANTHER; PTHR13408; PTHR13408; 1.
DR Pfam; PF05132; RNA_pol_Rpc4; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Antiviral defense; DNA-directed RNA polymerase; Immunity;
KW Innate immunity; Isopeptide bond; Methylation; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT CHAIN 2..398
FT /note="DNA-directed RNA polymerase III subunit RPC4"
FT /id="PRO_0000239118"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT MOD_RES 42
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT MOD_RES 95
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT MOD_RES 97
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT MOD_RES 99
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT CROSSLNK 68
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT CROSSLNK 78
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT CROSSLNK 141
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT CROSSLNK 152
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT CROSSLNK 160
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT CROSSLNK 190
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT CROSSLNK 199
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT CROSSLNK 206
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT CROSSLNK 220
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT CROSSLNK 285
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P05423"
FT CROSSLNK 302
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P05423"
SQ SEQUENCE 398 AA; 44549 MW; 0D757880454CA4CD CRC64;
MSEGNAAGEP SAPGGPRPLL SGARGLIGRR PAPPLTPGRL PSIRSRDLTL GGVKKKTFTP
NIISRKIKEE PKEEVTVKKE KRERDRDRQR DSHGRGRGRP EVIQSHSIFE QGPAEMMKKK
GNWDKTVDMS DVGPSHIINI KKEKRETDEE TKQILRMLEK DDFIDDPGLR NDIRNMPVQL
PLAHSGWLFK EENEETDVKP RLAGPKEEDM EVDMPAVKVK EEPRDEDEEA KMKAPLRAAR
KIPGLPKDVS VAELLRELSL TQEEELLFLQ LPDSLPGQPP TQDIKPIKTE VQSEDGQMVV
IKQEKDREAR LAENTCTLAD LTEGQVGKLL IRKSGKVQLL LGKVTLDVTM GTTCSFLQEL
VSVGLGDSRT GDMTVLGHIK HKLVCSPNFE SLLDHRHR
