RPC4_DICDI
ID RPC4_DICDI Reviewed; 430 AA.
AC Q8T1V7; Q54ZC1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 2.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=DNA-directed RNA polymerase III subunit rpc4;
DE Short=RNA polymerase III subunit C4;
DE AltName: Full=DNA-directed RNA polymerase III subunit D;
GN Name=polr3d; Synonyms=rpc4; ORFNames=DDB_G0277671;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Specific component of RNA polymerase III which synthesizes small RNAs,
CC such as 5S rRNA and tRNAs (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC consisting of 17 subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPC4/POLR3D RNA polymerase
CC subunit family. {ECO:0000305}.
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DR EMBL; AAFI02000020; EAL68653.1; -; Genomic_DNA.
DR RefSeq; XP_642576.1; XM_637484.1.
DR AlphaFoldDB; Q8T1V7; -.
DR STRING; 44689.DDB0220005; -.
DR PaxDb; Q8T1V7; -.
DR EnsemblProtists; EAL68653; EAL68653; DDB_G0277671.
DR GeneID; 8621139; -.
DR KEGG; ddi:DDB_G0277671; -.
DR dictyBase; DDB_G0277671; rpc4.
DR HOGENOM; CLU_638457_0_0_1; -.
DR InParanoid; Q8T1V7; -.
DR OMA; DPRKIMK; -.
DR Reactome; R-DDI-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-DDI-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR PRO; PR:Q8T1V7; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005666; C:RNA polymerase III complex; ISS:dictyBase.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; ISS:dictyBase.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:dictyBase.
DR InterPro; IPR007811; RPC4.
DR PANTHER; PTHR13408; PTHR13408; 1.
DR Pfam; PF05132; RNA_pol_Rpc4; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..430
FT /note="DNA-directed RNA polymerase III subunit rpc4"
FT /id="PRO_0000330757"
FT REGION 1..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 47075 MW; 1B9F53D157DBC34D CRC64;
MSEPPQPPGK PSANAPKPAP RLKSIKPTTP GDANKITTPT IPSIKTKKEF KPNIPTARKK
KDEKDPLSGA ISDLISASLS PLAVVGDRPG KPNATSSGKF RSNLNPNRKK PAAIPITNLF
QTPLVQAETQ QPQSTYEMNK KNEKKDSDLL AQLFHEMEVD PMQPFHPTHL PLVDPRKIMK
AYSLDDASKD LNETKRELEE KIKNGELSDT TNFTLNSIGS EDNNNNGGGS GQVKFVESSK
KKNKEISTKD KPFYVEDQFL NKDKLFFIQL PNLLPSTQSK PNFNIPNPVL PPPKPTTITK
TVTNPDGSIT TTTIPINENT KIEDQPPPPP KELDEKAFVP VIYPGDFPPS IKEMPSGKLG
TLKIYKSGKS ILKIGTVEYD ISSGDKLKFL EEVQCFQTKG GPDNSPTCYT LGIPSQHLVA
APIISQISGI
