RPC4_SCHPO
ID RPC4_SCHPO Reviewed; 330 AA.
AC O74857;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=DNA-directed RNA polymerase III subunit rpc4;
DE Short=RNA polymerase III subunit C4;
DE AltName: Full=RNA polymerase III subunit C53;
GN Name=rpc53; Synonyms=rpc4; ORFNames=SPCC18.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=16877568; DOI=10.1093/nar/gkl421;
RA Proshkina G.M., Shematorova E.K., Proshkin S.A., Zaros C., Thuriaux P.,
RA Shpakovski G.V.;
RT "Ancient origin, functional conservation and fast evolution of DNA-
RT dependent RNA polymerase III.";
RL Nucleic Acids Res. 34:3615-3624(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Specific peripheric component of RNA polymerase III which synthesizes
CC small RNAs, such as 5S rRNA and tRNAs. Essential for tRNA synthesis.
CC The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator
CC recognition and reinitiation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC consisting of 17 subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
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DR EMBL; DQ156224; ABA54852.1; -; mRNA.
DR EMBL; CU329672; CAA21421.1; -; Genomic_DNA.
DR PIR; T41150; T41150.
DR RefSeq; NP_588386.1; NM_001023377.2.
DR AlphaFoldDB; O74857; -.
DR BioGRID; 275432; 4.
DR DIP; DIP-29539N; -.
DR IntAct; O74857; 2.
DR STRING; 4896.SPCC18.07.1; -.
DR iPTMnet; O74857; -.
DR MaxQB; O74857; -.
DR PaxDb; O74857; -.
DR EnsemblFungi; SPCC18.07.1; SPCC18.07.1:pep; SPCC18.07.
DR GeneID; 2538851; -.
DR KEGG; spo:SPCC18.07; -.
DR PomBase; SPCC18.07; rpc53.
DR VEuPathDB; FungiDB:SPCC18.07; -.
DR eggNOG; KOG3122; Eukaryota.
DR HOGENOM; CLU_834605_0_0_1; -.
DR InParanoid; O74857; -.
DR OMA; ESKRMWN; -.
DR PhylomeDB; O74857; -.
DR Reactome; R-SPO-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-SPO-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR PRO; PR:O74857; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005666; C:RNA polymerase III complex; ISO:PomBase.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISO:PomBase.
DR InterPro; IPR007811; RPC4.
DR PANTHER; PTHR13408; PTHR13408; 1.
DR Pfam; PF05132; RNA_pol_Rpc4; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA-directed RNA polymerase; Nucleus; Reference proteome;
KW Transcription.
FT CHAIN 1..330
FT /note="DNA-directed RNA polymerase III subunit rpc4"
FT /id="PRO_0000351044"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 330 AA; 36871 MW; 02FD89911B156616 CRC64;
MRKFTPKFVP RRKNGPVEEK DVDERVKIEF DVESQKKWKA SRPKPEIKLT ASGPFALGPN
ASSSGTGRPI GSVYVPPPNV KNEEKDDALS KLAASSGHDE GHDEDMVDIL KLRELNGQEQ
GKTDIGGKDL LVPIITDRML PESNDEKLKH HAESAIHTTV INKEDEEQER VALDLQSLAQ
HLGLTEQEGM EDHFKDQMVL MQFPDKLPRF MGDADVDPVW PSSEVKEEEA GEKTDVEEKK
DPDKHGRENG NIDDLTSLPY PAFHPPAGQI GVLRVHQSGK TTLEMGGVNF VVQSGSDCLF
LQEIAVVDYD SKRIWNLGSF ERRMIVSPDF
