RPC5_SCHPO
ID RPC5_SCHPO Reviewed; 242 AA.
AC O74883;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=DNA-directed RNA polymerase III subunit rpc5;
DE Short=RNA polymerase III subunit C5;
DE AltName: Full=RNA polymerase III subunit C37;
GN Name=rpc37; ORFNames=SPCC330.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Specific peripheric component of RNA polymerase III which synthesizes
CC small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5
CC subcomplex is required for terminator recognition and reinitiation (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC consisting of 17 subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329672; CAA20918.1; -; Genomic_DNA.
DR PIR; T41323; T41323.
DR RefSeq; NP_587713.1; NM_001022708.2.
DR AlphaFoldDB; O74883; -.
DR SMR; O74883; -.
DR BioGRID; 275463; 6.
DR IntAct; O74883; 1.
DR STRING; 4896.SPCC330.13.1; -.
DR iPTMnet; O74883; -.
DR MaxQB; O74883; -.
DR PaxDb; O74883; -.
DR PRIDE; O74883; -.
DR EnsemblFungi; SPCC330.13.1; SPCC330.13.1:pep; SPCC330.13.
DR GeneID; 2538885; -.
DR KEGG; spo:SPCC330.13; -.
DR PomBase; SPCC330.13; rpc37.
DR VEuPathDB; FungiDB:SPCC330.13; -.
DR eggNOG; KOG2354; Eukaryota.
DR HOGENOM; CLU_1161721_0_0_1; -.
DR InParanoid; O74883; -.
DR OMA; PKTGWME; -.
DR PhylomeDB; O74883; -.
DR PRO; PR:O74883; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005666; C:RNA polymerase III complex; ISO:PomBase.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; ISO:PomBase.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISO:PomBase.
DR InterPro; IPR006886; RNA_pol_III_Rpc5.
DR PANTHER; PTHR12069; PTHR12069; 1.
DR Pfam; PF04801; RPC5; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-directed RNA polymerase; Nucleus; Reference proteome;
KW Transcription.
FT CHAIN 1..242
FT /note="DNA-directed RNA polymerase III subunit rpc5"
FT /id="PRO_0000357058"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 242 AA; 27385 MW; E44C0BFA6824D279 CRC64;
MSFSEDQAME EAKLRNDETE EQDPVVRTYP VFFSPGLRNN LLLNQFPLRP KNRTYSDANG
EAPIDVRVKP KTGWMEVDVP IPTTKYYNED KAMKYGNGKK PIQTQTLSGR LQKPRTNLMV
GLIRDGQFHI VPLRGLTQLR PSMKHVNEYT QKLKAAAGPS NSSSGTSTPR GPIRAVQVTA
KQNTEAPKVS TTHIVRATEE EEWVELDCRP ERESESILKQ LECPIEHQPN ECAAVDEDYS
FI
