ID   RPC6_BOVIN              Reviewed;         316 AA.
AC   Q2T9S3;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=DNA-directed RNA polymerase III subunit RPC6;
DE            Short=RNA polymerase III subunit C6;
DE   AltName: Full=DNA-directed RNA polymerase III subunit F;
GN   Name=POLR3F;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific peripheric component of RNA polymerase III which synthesizes
CC       small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding
CC       to the TFIIIB-DNA complex. Plays a key role in sensing and limiting
CC       infection by intracellular bacteria and DNA viruses. Acts as nuclear
CC       and cytosolic DNA sensor involved in innate immune response. Can sense
CC       non-self dsDNA that serves as template for transcription into dsRNA.
CC       The non-self RNA polymerase III transcripts induce type I interferon
CC       and NF- Kappa-B through the RIG-I pathway (By similarity).
CC       Preferentially binds double-stranded DNA (dsDNA) (By similarity).
CC       {ECO:0000250, ECO:0000250|UniProtKB:Q9H1D9}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G
CC       form a Pol III subcomplex (By similarity). Directly interacts with
CC       POLR3C (By similarity). Interacts with TBP and TFIIIB90 and GTF3C4 (By
CC       similarity). Interacts with MAF1 (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:Q9H1D9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase
CC       subunit family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC111292; AAI11293.1; -; mRNA.
DR   RefSeq; NP_001033237.1; NM_001038148.1.
DR   AlphaFoldDB; Q2T9S3; -.
DR   SMR; Q2T9S3; -.
DR   STRING; 9913.ENSBTAP00000011619; -.
DR   PaxDb; Q2T9S3; -.
DR   PRIDE; Q2T9S3; -.
DR   GeneID; 529410; -.
DR   KEGG; bta:529410; -.
DR   CTD; 10621; -.
DR   eggNOG; KOG3233; Eukaryota.
DR   InParanoid; Q2T9S3; -.
DR   OrthoDB; 1287786at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005666; C:RNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0045089; P:positive regulation of innate immune response; ISS:UniProtKB.
DR   GO; GO:0032728; P:positive regulation of interferon-beta production; ISS:UniProtKB.
DR   GO; GO:0006383; P:transcription by RNA polymerase III; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR007832; RNA_pol_Rpc34.
DR   InterPro; IPR016049; RNA_pol_Rpc34-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12780; PTHR12780; 1.
DR   Pfam; PF05158; RNA_pol_Rpc34; 1.
DR   PIRSF; PIRSF028763; RNA_pol_Rpc34; 1.
DR   SUPFAM; SSF46785; SSF46785; 2.
PE   2: Evidence at transcript level;
KW   Acetylation; Antiviral defense; DNA-directed RNA polymerase; Immunity;
KW   Innate immunity; Isopeptide bond; Nucleus; Reference proteome;
KW   Transcription; Ubl conjugation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H1D9"
FT   CHAIN           2..316
FT                   /note="DNA-directed RNA polymerase III subunit RPC6"
FT                   /id="PRO_0000246167"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H1D9"
FT   CROSSLNK        5
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H1D9"
FT   CROSSLNK        7
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H1D9"
SQ   SEQUENCE   316 AA;  35684 MW;  58412D80C1FA691D CRC64;
     MAEVKVKVQP PDADPVEIEN RIIELCHQFP HGITDQVIQN EMPHIEAQQR AVAINRLLSM
     GQLDLLRSNT GLLYRIKDSQ NAGKMKGSDN QEKLVYQIIE DAGNKGIWSR DIRYKSNLPL
     TEINKILKNL ESKKLIKAVK SVAASKKKVY MLYNLQPDRS VTGGAWYSDQ DFESEFVEVL
     NQQCFKFLQN KAETARESKQ NPMIQRNSSF ASSHEVWKYI CELGISKVEL SMEDIETILN
     TLIYDGKVEM TIIAAKEGTV GSVDGHMKLY RAVSPIIPPT GLVRAPCGLC PVFDDCHEGG
     EISPSNCIYM TEWLEF