RPC7L_MOUSE
ID RPC7L_MOUSE Reviewed; 218 AA.
AC Q8R0C0; Q9D8G0;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=DNA-directed RNA polymerase III subunit RPC7-like;
DE Short=RNA polymerase III subunit C7-like;
DE AltName: Full=DNA-directed RNA polymerase III subunit G-like;
GN Name=Polr3gl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=24107381; DOI=10.1101/gr.161570.113;
RA Renaud M., Praz V., Vieu E., Florens L., Washburn M.P., l'Hote P.,
RA Hernandez N.;
RT "Gene duplication and neofunctionalization: POLR3G and POLR3GL.";
RL Genome Res. 24:37-51(2014).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Specific peripheric component of RNA polymerase III which synthesizes
CC small RNAs, such as 5S rRNA and tRNAs. {ECO:0000250|UniProtKB:Q9BT43}.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC consisting of 17 subunits (By similarity). Found a trimeric complex
CC with POLR3C and POLR3G. Directly interacts with POLR3C (By similarity).
CC {ECO:0000250, ECO:0000250|UniProtKB:Q9BT43}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BT43}.
CC -!- TISSUE SPECIFICITY: Expressed in the liver.
CC {ECO:0000269|PubMed:24107381}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPC7 RNA polymerase subunit
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH27083.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK008069; BAB25439.1; -; mRNA.
DR EMBL; BC027083; AAH27083.1; ALT_FRAME; mRNA.
DR CCDS; CCDS17641.1; -.
DR RefSeq; NP_081517.2; NM_027241.4.
DR AlphaFoldDB; Q8R0C0; -.
DR SMR; Q8R0C0; -.
DR STRING; 10090.ENSMUSP00000089544; -.
DR iPTMnet; Q8R0C0; -.
DR PhosphoSitePlus; Q8R0C0; -.
DR PaxDb; Q8R0C0; -.
DR PRIDE; Q8R0C0; -.
DR ProteomicsDB; 299868; -.
DR DNASU; 69870; -.
DR Ensembl; ENSMUST00000091924; ENSMUSP00000089544; ENSMUSG00000028104.
DR GeneID; 69870; -.
DR KEGG; mmu:69870; -.
DR UCSC; uc008qnf.3; mouse.
DR CTD; 84265; -.
DR MGI; MGI:1917120; Polr3gl.
DR VEuPathDB; HostDB:ENSMUSG00000028104; -.
DR eggNOG; ENOG502QUPX; Eukaryota.
DR GeneTree; ENSGT00940000165934; -.
DR HOGENOM; CLU_084309_0_0_1; -.
DR InParanoid; Q8R0C0; -.
DR OMA; DKYNRSE; -.
DR OrthoDB; 1403784at2759; -.
DR PhylomeDB; Q8R0C0; -.
DR TreeFam; TF103052; -.
DR Reactome; R-MMU-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-MMU-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR Reactome; R-MMU-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR BioGRID-ORCS; 69870; 7 hits in 70 CRISPR screens.
DR ChiTaRS; Polr3gl; mouse.
DR PRO; PR:Q8R0C0; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8R0C0; protein.
DR Bgee; ENSMUSG00000028104; Expressed in retinal neural layer and 230 other tissues.
DR ExpressionAtlas; Q8R0C0; baseline and differential.
DR Genevisible; Q8R0C0; MM.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005666; C:RNA polymerase III complex; ISO:MGI.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR InterPro; IPR024661; RNA_pol_III_Rpc31.
DR PANTHER; PTHR15367; PTHR15367; 1.
DR Pfam; PF11705; RNA_pol_3_Rpc31; 1.
DR PIRSF; PIRSF000777; RNA_polIII_C31; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..218
FT /note="DNA-directed RNA polymerase III subunit RPC7-like"
FT /id="PRO_0000311591"
FT REGION 130..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..197
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..218
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 83
FT /note="P -> S (in Ref. 1; BAB25439)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="P -> S (in Ref. 1; BAB25439)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="E -> G (in Ref. 1; BAB25439)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="E -> G (in Ref. 1; BAB25439)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 218 AA; 25136 MW; 9CB9C55283671755 CRC64;
MASRGGGRGR GRGQLTFNME AVGIGKGDAL PPPTLQPSPL FPPLEFHPVP LPAGEEGEYV
LALKQELRGA MRQLPYFIRP AVPKRDVERY SDKYQMSGPI DNAIDWNPDW RRLPSELKIR
VRKVQKERTT IILPKRPPKS TDDKEETIQK LETLEKKEEE VTSEEDEEKE EEEEKEEGEE
EEYDEEEHEE ETDYIMSYFD NGEDFGGDSD DNMDEAIY
