ID   RPC8_BOVIN              Reviewed;         204 AA.
AC   Q2T9X1;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA-directed RNA polymerase III subunit RPC8;
DE            Short=RNA polymerase III subunit C8;
DE   AltName: Full=DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide;
DE   AltName: Full=DNA-directed RNA polymerase III subunit H;
GN   Name=POLR3H;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific peripheric component of RNA polymerase III which synthesizes
CC       small RNAs, such as 5S rRNA and tRNA. Plays a key role in sensing and
CC       limiting infection by intracellular bacteria and DNA viruses. Acts as
CC       nuclear and cytosolic DNA sensor involved in innate immune response.
CC       Can sense non-self dsDNA that serves as template for transcription into
CC       dsRNA. The non-self RNA polymerase III transcripts induce type I
CC       interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. Interacts with RPC9 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit
CC       family. {ECO:0000305}.
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DR   EMBL; BC111227; AAI11228.1; -; mRNA.
DR   RefSeq; NP_001070430.1; NM_001076962.2.
DR   AlphaFoldDB; Q2T9X1; -.
DR   SMR; Q2T9X1; -.
DR   STRING; 9913.ENSBTAP00000006987; -.
DR   PaxDb; Q2T9X1; -.
DR   GeneID; 767843; -.
DR   KEGG; bta:767843; -.
DR   CTD; 171568; -.
DR   eggNOG; KOG3297; Eukaryota.
DR   InParanoid; Q2T9X1; -.
DR   OrthoDB; 1430056at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.30.1490.120; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR013238; RNA_pol_III_Rbc25.
DR   InterPro; IPR036898; RNA_pol_Rpb7-like_N_sf.
DR   InterPro; IPR004519; RNAP_E/RPC8.
DR   InterPro; IPR045113; Rpb7-like.
DR   InterPro; IPR005576; Rpb7-like_N.
DR   PANTHER; PTHR12709; PTHR12709; 1.
DR   Pfam; PF08292; RNA_pol_Rbc25; 1.
DR   Pfam; PF03876; SHS2_Rpb7-N; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF88798; SSF88798; 1.
DR   TIGRFAMs; TIGR00448; rpoE; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; DNA-directed RNA polymerase; Immunity; Innate immunity;
KW   Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..204
FT                   /note="DNA-directed RNA polymerase III subunit RPC8"
FT                   /id="PRO_0000285782"
FT   REGION          158..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..173
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   204 AA;  23027 MW;  A6903534F32B1680 CRC64;
     MFVLVEMVDT VRIPPWQFER KLNDSIDEEL NKKLANKVMY NVGLCICLFD ITKLEDAYVF
     PGDGASHTKV HFRYVVFHPF LDEILIGKIK GCSPEGVHVS LGFFDDILIP PESLQQPAKF
     DEAEQVWVWE YETEEGAHDL YMDIGEEVRF RVVDESFVDT SPTGPSSAEA ASSSEELPKK
     EAPYTLMGSI SEPGLGLLSW WTSS