RPC8_DICDI
ID RPC8_DICDI Reviewed; 252 AA.
AC Q557J3; Q86KI8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=DNA-directed RNA polymerase III subunit rpc8;
DE Short=RNA polymerase III subunit C8;
DE AltName: Full=DNA-directed RNA polymerase III subunit H;
GN Name=polr3h-1; Synonyms=rpc25, rpc8; ORFNames=DDB_G0273425;
GN and
GN Name=polr3h-2; Synonyms=rpc25, rpc8; ORFNames=DDB_G0273523;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC consisting of several subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit
CC family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000010; EAL70667.1; -; Genomic_DNA.
DR EMBL; AAFI02000010; EAL70716.1; -; Genomic_DNA.
DR RefSeq; XP_644608.1; XM_639516.1.
DR RefSeq; XP_644642.1; XM_639550.1.
DR AlphaFoldDB; Q557J3; -.
DR SMR; Q557J3; -.
DR STRING; 44689.DDB0216296; -.
DR PaxDb; Q557J3; -.
DR EnsemblProtists; EAL70667; EAL70667; DDB_G0273425.
DR EnsemblProtists; EAL70716; EAL70716; DDB_G0273523.
DR GeneID; 8618972; -.
DR GeneID; 8619005; -.
DR KEGG; ddi:DDB_G0273425; -.
DR KEGG; ddi:DDB_G0273523; -.
DR dictyBase; DDB_G0273425; rpc25-1.
DR dictyBase; DDB_G0273523; rpc25-2.
DR eggNOG; KOG3297; Eukaryota.
DR HOGENOM; CLU_073901_1_1_1; -.
DR InParanoid; Q557J3; -.
DR OMA; LGPTLWW; -.
DR PhylomeDB; Q557J3; -.
DR Reactome; R-DDI-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-DDI-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR PRO; PR:Q557J3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005666; C:RNA polymerase III complex; ISS:dictyBase.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; ISS:dictyBase.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; ISS:dictyBase.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.30.1490.120; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR013238; RNA_pol_III_Rbc25.
DR InterPro; IPR036898; RNA_pol_Rpb7-like_N_sf.
DR InterPro; IPR045113; Rpb7-like.
DR InterPro; IPR005576; Rpb7-like_N.
DR PANTHER; PTHR12709; PTHR12709; 1.
DR Pfam; PF08292; RNA_pol_Rbc25; 1.
DR Pfam; PF03876; SHS2_Rpb7-N; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR SUPFAM; SSF88798; SSF88798; 1.
PE 2: Evidence at transcript level;
KW DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..252
FT /note="DNA-directed RNA polymerase III subunit rpc8"
FT /id="PRO_0000328174"
FT REGION 214..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..252
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 252 AA; 28835 MW; A3F3DDCA6DF7E7C4 CRC64;
MFHLITIEDK VRIAPSQFNN EVQTIEDEIE KKYTSKVVLN AGLFVALYDI LGTGDSYVHS
GDGGAHLMVR FRMVVFKPFK GEVLEGVIKK SSRQSIQISL GFFHEIYLNP IELPNPSNYN
QEEGLWYWEW NENQLFFEDG GRVRFKIDQV EFNPEISQPA PSPKNVNTEA MDSYSLREYK
EKQIENENLL KQVKSPLILK VSMREAGLGM VSWWTNQSAG DDDENEEDGG ENQDDEVAED
DGGEEPTIEE DE
