ID   RPC9_BOVIN              Reviewed;         148 AA.
AC   A0JN61;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA-directed RNA polymerase III subunit RPC9;
DE            Short=RNA polymerase III subunit C9;
GN   Name=CRCP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Specific peripheric component of RNA polymerase III which synthesizes
CC       small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and
CC       limiting infection by intracellular bacteria and DNA viruses. Acts as
CC       nuclear and cytosolic DNA sensor involved in innate immune response.
CC       Can sense non-self dsDNA that serves as template for transcription into
CC       dsRNA. The non-self RNA polymerase III transcripts induce type I
CC       interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC       consisting of 17 subunits. Interacts with POLR3H/RPC8. POLR3H/RPC8 and
CC       CRCP/RPC9 probably form a Pol III subcomplex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPC9 RNA polymerase subunit
CC       family. {ECO:0000305}.
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DR   EMBL; BC126530; AAI26531.1; -; mRNA.
DR   RefSeq; NP_001071338.1; NM_001077870.1.
DR   AlphaFoldDB; A0JN61; -.
DR   SMR; A0JN61; -.
DR   STRING; 9913.ENSBTAP00000048749; -.
DR   PaxDb; A0JN61; -.
DR   PRIDE; A0JN61; -.
DR   Ensembl; ENSBTAT00000053944; ENSBTAP00000048749; ENSBTAG00000037489.
DR   GeneID; 507533; -.
DR   KEGG; bta:507533; -.
DR   CTD; 27297; -.
DR   VEuPathDB; HostDB:ENSBTAG00000037489; -.
DR   VGNC; VGNC:27691; CRCP.
DR   eggNOG; KOG4168; Eukaryota.
DR   GeneTree; ENSGT00390000014189; -.
DR   HOGENOM; CLU_092529_5_0_1; -.
DR   InParanoid; A0JN61; -.
DR   OMA; VMIINLR; -.
DR   TreeFam; TF323294; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000037489; Expressed in oocyte and 103 other tissues.
DR   GO; GO:0009360; C:DNA polymerase III complex; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005666; C:RNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; ISS:UniProtKB.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006383; P:transcription by RNA polymerase III; ISS:UniProtKB.
DR   GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; IBA:GO_Central.
DR   Gene3D; 1.20.1250.40; -; 1.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR006590; RNA_pol_Rpb4/RPC9_core.
DR   InterPro; IPR005574; Rpb4/RPC9.
DR   InterPro; IPR038324; Rpb4/RPC9_sf.
DR   InterPro; IPR038846; RPC9.
DR   PANTHER; PTHR15561; PTHR15561; 1.
DR   Pfam; PF03874; RNA_pol_Rpb4; 1.
DR   SMART; SM00657; RPOL4c; 1.
DR   SUPFAM; SSF47819; SSF47819; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cell membrane; DNA-directed RNA polymerase; Immunity;
KW   Innate immunity; Membrane; Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..148
FT                   /note="DNA-directed RNA polymerase III subunit RPC9"
FT                   /id="PRO_0000328050"
FT   REGION          125..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   148 AA;  16745 MW;  84941C2C7E76EA24 CRC64;
     MEVKDANAAL LSNYEVFQLL TDLKEQRKES GKNKHSSGQQ NLNTITYETL KYISKTPCKH
     QSPEIVREFL TAMKSHKLTK AEKLQLLNHR PVTAVEIQLM VEESEERLTE EQIEALLHTV
     TSILPAGPEA EQQQNASDDV AMDEEDPA